Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame

Plasma Concentrations and Pharmacokinetics of Phenylalanine in Rats and Mice Administered Aspartame

“…The Cmaxs. Tmaxs and AUCs for PHE and tyro sine at the 200 and 1,000 mg/kg doses of aspartame were generally the same as those calculated from data reported by Romano et al [29] who administered bolus doses of 250 and 1.000 mg/kg of aspartame to rats. How ever, at 1.000 mg/kg, Romano et al [29] reported plasma concentrations of PHE that were approximately one half of the current values and AUCs that were not directly pro portional to the aspartame dose.…”

Plasma Concentrations and Pharmacokinetics of Phenylalanine in Rats and Mice Administered Aspartame

“…The Cmaxs. Tmaxs and AUCs for PHE and tyro sine at the 200 and 1,000 mg/kg doses of aspartame were generally the same as those calculated from data reported by Romano et al [29] who administered bolus doses of 250 and 1.000 mg/kg of aspartame to rats. How ever, at 1.000 mg/kg, Romano et al [29] reported plasma concentrations of PHE that were approximately one half of the current values and AUCs that were not directly pro portional to the aspartame dose.…”

Synthetic Sweeteners and Human Health: An Overview of Health Risks, Vulnerable Populations, and Effects on Key Biological Systems

“…A study by Romano et al reported several adverse effects of aspartame on the central nervous system [ 119 ]. These include headaches, mood swings, sleep disturbances, seizures, personality changes, dizziness, and vision problems [ 119 ].…”

Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans

“…Saccharin, sucralose, and AceK, for example, remain almost completely unmetabolized, and thus are mainly excreted from the body in their original form. But aspartame is rapidly metabolized in the upper intestinal mucosa into its three main constituents – phenylalanine, aspartic acid, and methanol – and significant elevations of the amino acids, both in plasma and in the brain, have been detected for at least an hour following bolus ingestion in rodents [27,28]. These differences have likely contributed to the differential impacts reported for LCSs on weight change, glucose homeostasis, and the gut microbiota in various studies.…”

Plasma Concentrations and Pharmacokinetics of Phenylalanine in Rats and Mice Administered Aspartame

“…The Cmaxs. Tmaxs and AUCs for PHE and tyro sine at the 200 and 1,000 mg/kg doses of aspartame were generally the same as those calculated from data reported by Romano et al [29] who administered bolus doses of 250 and 1.000 mg/kg of aspartame to rats. How ever, at 1.000 mg/kg, Romano et al [29] reported plasma concentrations of PHE that were approximately one half of the current values and AUCs that were not directly pro portional to the aspartame dose.…”

Synthetic Sweeteners and Human Health: An Overview of Health Risks, Vulnerable Populations, and Effects on Key Biological Systems

“…A study by Romano et al reported several adverse effects of aspartame on the central nervous system [ 119 ]. These include headaches, mood swings, sleep disturbances, seizures, personality changes, dizziness, and vision problems [ 119 ].…”

Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans

“…Saccharin, sucralose, and AceK, for example, remain almost completely unmetabolized, and thus are mainly excreted from the body in their original form. But aspartame is rapidly metabolized in the upper intestinal mucosa into its three main constituents – phenylalanine, aspartic acid, and methanol – and significant elevations of the amino acids, both in plasma and in the brain, have been detected for at least an hour following bolus ingestion in rodents [27,28]. These differences have likely contributed to the differential impacts reported for LCSs on weight change, glucose homeostasis, and the gut microbiota in various studies.…”

Plasma Concentrations and Pharmacokinetics of Phenylalanine in Rats and Mice Administered Aspartame

“…The Cmaxs. Tmaxs and AUCs for PHE and tyro sine at the 200 and 1,000 mg/kg doses of aspartame were generally the same as those calculated from data reported by Romano et al [29] who administered bolus doses of 250 and 1.000 mg/kg of aspartame to rats. How ever, at 1.000 mg/kg, Romano et al [29] reported plasma concentrations of PHE that were approximately one half of the current values and AUCs that were not directly pro portional to the aspartame dose.…”

Synthetic Sweeteners and Human Health: An Overview of Health Risks, Vulnerable Populations, and Effects on Key Biological Systems

“…A study by Romano et al reported several adverse effects of aspartame on the central nervous system [ 119 ]. These include headaches, mood swings, sleep disturbances, seizures, personality changes, dizziness, and vision problems [ 119 ].…”

Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans

“…Saccharin, sucralose, and AceK, for example, remain almost completely unmetabolized, and thus are mainly excreted from the body in their original form. But aspartame is rapidly metabolized in the upper intestinal mucosa into its three main constituents – phenylalanine, aspartic acid, and methanol – and significant elevations of the amino acids, both in plasma and in the brain, have been detected for at least an hour following bolus ingestion in rodents [27,28]. These differences have likely contributed to the differential impacts reported for LCSs on weight change, glucose homeostasis, and the gut microbiota in various studies.…”