2021
DOI: 10.1002/ehf2.13572
|View full text |Cite
|
Sign up to set email alerts
|

Plasma amino acid profiling improves predictive accuracy of adverse events in patients with heart failure

Abstract: AimsThe clinical outcome of heart failure (HF) is complicated by the presence of multiple comorbidities including malnutrition and cachexia, and prediction of the outcome is still difficult in each patient. Metabolomics including amino acid profiling enables detection of alterations in whole body metabolism. The aim of this study was to determine whether plasma amino acid profiling improves prediction of clinical outcomes in patients with HF. Methods and resultsWe retrospectively examined 301 HF patients (70 ±… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
35
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7

Relationship

4
3

Authors

Journals

citations
Cited by 19 publications
(37 citation statements)
references
References 44 publications
1
35
0
Order By: Relevance
“…9 ASM was calculated by DEXA (Horizon A DXA System, HOLOGIC, Waltham, MA, USA) as previously reported. 8,10 ASMI was defined as ASM/height 2 . The cut-off values of ASMI for low muscle mass were <7.00 and <5.40 kg/m 2 for men and women, respectively, according to the criteria of the Asian Working Group for Sarcopenia.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…9 ASM was calculated by DEXA (Horizon A DXA System, HOLOGIC, Waltham, MA, USA) as previously reported. 8,10 ASMI was defined as ASM/height 2 . The cut-off values of ASMI for low muscle mass were <7.00 and <5.40 kg/m 2 for men and women, respectively, according to the criteria of the Asian Working Group for Sarcopenia.…”
Section: Methodsmentioning
confidence: 99%
“…HF was diagnosed according to the 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic HF 9 . ASM was calculated by DEXA (Horizon A DXA System, HOLOGIC, Waltham, MA, USA) as previously reported 8,10 . ASMI was defined as ASM/height 2 .…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, a recently published cohort study observed that high 3-Me-His concentrations and low β-alanine and valine concentrations were independently associated with a significantly higher risk of a composite endpoint of all-cause death and readmission due to worsening HF or lethal arrhythmia in patients with HF. In addition, the inclusion of these amino acid levels in a multivariate model of clinical variables (including N-terminal proBNP levels) significantly improved its predictive capacity, highlighting the role of AAs as potential biomarkers for risk stratification in HF patients [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…After stabilization of HF, blood samples for measurements of amino acid concentrations were collected in a fasting state. Plasma amino acid concentrations were measured using ultraperformance liquid chromatography (LSI Medience Corporation, Tokyo, Japan) as previously described [ 20 , 27 , 28 ]. Blood samples were collected in sodium heparin tubes (NIPRO, Osaka, Japan) and transported to the laboratory at room temperature.…”
Section: Methodsmentioning
confidence: 99%
“…Therefore, plasma amino acid profiling is a useful approach for elucidating the pathogenesis of disease and response to treatment, as is omics [ 15 19 ]. Indeed, the results of our recent study showed that specific patterns of changes in circulating amino acid concentrations improved the predictive ability for adverse events [ 20 ], indicating the utility of plasma amino acid profiling in risk stratification of HF patients. Intriguingly, urinary amino acid concentrations have been shown to be modulated by genetic and pharmacological inhibition of SGLT2 [ 21 , 22 ], possibly leading to changes in plasma amino acid profiles.…”
Section: Introductionmentioning
confidence: 99%