Plasma Adiponectin Levels and Metabolic Factors in Nondiabetic Adolescents

Huang, Kuo‐Chin; Lue, Bee-Horng; Yen, Ruoh‐Fang; Shen, Christopher G.; Ho, Shiuh‐Rong; Tai, Tong-Yuan; Yang, Wei–Shiung

doi:10.1038/oby.2004.16

Cited by 63 publications

(60 citation statements)

References 51 publications

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“…However, the significant association observed among adiponectin and S i is impetus for future research on the potential contribution of lower adiponectin among African Americans to impairment in glucose tolerance and risk for type 2 diabetes. This is especially true in light of recent findings suggesting that circulating adiponectin levels predict insulin resistance in certain adolescent populations (44,45). For example, Mexican children and adolescents with higher levels of adiponectin had decreased prevalence of type 2 diabetes (45).…”

Section: Discussionmentioning

confidence: 82%

Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents

et al. 2005

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Adiponectin is inversely related to adiposity and positively correlated with insulin sensitivity (S i ). Sparse data exist on the contributions of ethnicity and body fat distribution to variance in serum adiponectin. Hypotheses tested were that adiponectin would be lower in African Americans compared with Caucasians; that adiponectin would be inversely related to central, not peripheral, fat; that adiponectin would be positively associated with S i ; and that baseline adiponectin would predict change in S i over 2 years in 150 African-American and Caucasian youth. Multiple linear regression modeling showed that adiponectin was lower in AfricanAmerican versus Caucasian children (adjusted means 10.8 ؎ 0.5 vs. 12.3 ؎ 0.5 g/ml, respectively; P < 0.05); inversely related to trunk fat (P < 0.05); and positively related to limb fat (P < 0.01). Addition of the acute insulin response to glucose to the model eliminated the significance of ethnicity. S i , which was positively related to adiponectin (P < 0.05), was lower in African Americans (P < 0.001) and girls (P < 0.05). Baseline adiponectin did not predict change in S i over 2 years. In conclusion, adiponectin was positively correlated with S i , inversely related to central fat, and positively related to peripheral fat. In addition, higher acute insulin response to glucose explained lower adiponectin among African-American children.

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Section: Discussionmentioning

confidence: 82%

Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents

et al. 2005

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“…93 Visceral fat measured in a small sample of adolescent girls 94 was associated with dyslipidemia and glucose intolerance, especially in the obese. Waist circumference has also been associated with inflammatory biomarkers such as CRP 95 and adiponectin 96,97 in youth. Given the significant increase in waist circumference among US children and adolescents over the past 2 decades, 98 a marker of abdominal obesity should be considered as an important component of the pediatric MetS definition.…”

Section: Obesitymentioning

confidence: 99%

Progress and Challenges in Metabolic Syndrome in Children and Adolescents

Steinberger¹,

Daniels²,

Eckel³

et al. 2009

Circulation

616

278

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“…All four of the previously mentioned cytokines have been associated with body fat indicators in youth [4,5,[7][8][9]18]. Therefore, it could be expected that the strength of the association between cytokines and insulin resistance is higher in overweight compared to normal weight youth.…”

Section: Introductionmentioning

confidence: 99%

“…However, the link between adipose tissue and the increased resistance to insulin is still unclear [2][3]. Cytokines released by the adipose tissue, such as adiponectin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), appear to link adiposity with insulin resistance in youth [4][5][6][7][8], as in adults [3,[10][11][12][13][14][15]. Adiponectin increases glucose uptake and free fatty acid oxidation in skeletal muscle [16] and is associated with decreased insulin resistance in youth and adults [4,5,8,10].…”

Section: Introductionmentioning

confidence: 99%

The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise

et al. 2008

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Increased adiposity is associated with insulin resistance (IR) and an inflammatory response in adults. We tested the hypotheses that cytokines associated with adiposity are also correlated with IR in early adolescents and that these relationships are moderated by weight status, levels of vigorous physical activity (VPA), or maximal aerobic power (pVO 2 max). Body mass, stature, and a fasting blood sample were obtained from 120 mid-pubertal adolescents (60 girls & 60 boys). Habitual VPA was obtained by a survey. Predicted VO 2 max was determined using a cycle-ergometer test. Weight status was based on body mass index percentiles (normal weight = BMI < 75 th %tile and overweight = BMI > 95th %tile). Glucose, insulin, adiponectin, resistin, tumor necrosis factor-α, and interleukin-6 were measured, and IR index was based on the Homeostatic Model Assessment (HOMA). Adiponectin, resistin and TNF-α were associated with IR in all adolescents (R 2 =0.329, p<0.001, R 2 =0.152, p=0.001, R 2 =0.141, p=0.002; respectively), but IL-6 was not (R 2 =0.148, p=0.114). The degree of association between adiponectin and IR was stronger in overweight than in normal weight adolescents (p<0.050). When regression models included weight status, neither TNF-α nor resistin were significantly related to IR (p>0.050). Exercise did not moderate the association between these cytokines and IR. However, higher levels of VPA and/or pVO 2 max were associated with higher adiponectin, lower resistin and lower TNF-α in at least one of the genders. Our results indicate that the pathophysiology of obesity is already established in early adolescents. Increased adiposity, resulting in reduced adiponectin and increased resistin and TNF-α may link these cytokines with insulin resistance in adolescents.

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Plasma Adiponectin Levels and Metabolic Factors in Nondiabetic Adolescents

Cited by 63 publications

References 51 publications

Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents

Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents

Progress and Challenges in Metabolic Syndrome in Children and Adolescents

The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise

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