2016
DOI: 10.1371/journal.pone.0148873
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Abstract: BackgroundThelper1 (Th1) lymphocytes have been previously implicated in atherosclerotic plaque growth but their role in plaque vulnerability to rupture is less clear. We investigated whether T-bet knockout that prevents Th1 lymphocyte differentiation modulates classical (M1) macrophage activation or production of matrix degrading metalloproteinases (MMPs) and their tissue inhibitors, TIMPs.Methods & ResultsWe studied the effect of T-bet deletion in apolipoproteinE (ApoE) knockout mice fed a high fat diet (HFD)… Show more

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Cited by 6 publications
(10 citation statements)
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“…) or only T‐helper‐1 cells (Tsaousi et al . ) did not affect MMP or TIMP expression in mouse foam cells from subcutaneous granulomas or in atherosclerotic plaques. Consequently, the evidence for stimulatory effects of IFNγ on MMP expression is stronger in humans than in mice.…”
Section: Introductionmentioning
confidence: 85%
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“…) or only T‐helper‐1 cells (Tsaousi et al . ) did not affect MMP or TIMP expression in mouse foam cells from subcutaneous granulomas or in atherosclerotic plaques. Consequently, the evidence for stimulatory effects of IFNγ on MMP expression is stronger in humans than in mice.…”
Section: Introductionmentioning
confidence: 85%
“…), whereas MMPs‐12, ‐13 and ‐23 are much higher in mice (Tsaousi et al . ). The high levels of MMP‐12 and ‐13 expression in mouse macrophages correspond to dramatic effects on atherosclerosis (Johnson et al .…”
Section: Introductionmentioning
confidence: 97%
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“…In addition, previous studies showed that T cells become dispensable for atherosclerosis development after prolonged and severe hypercholesterolemia. 36,37 More recently, Tsaousi et al 38 reported that when Apoe −/− mice were fed a chow diet for 35 weeks, lesions were approximately the same size as after 12 weeks of HFD. Yet, T-bet-deficient Apoe −/− mice, in which T cells are unable to differentiate into a Th1 phenotype, exhibited fewer plaques compared with immunocompetent Apoe −/− mice after 35 weeks of chow diet, whereas T-bet deficiency had no atheroprotective effects in Apoe −/− mice fed a HFD for 12 weeks.…”
Section: Haddad Et Al Dngr-1 Il-10 and Atherosclerosis 241mentioning
confidence: 99%