Plantas Medicinais da RENISUS Com Potencial Anti-inflamatório: Revisão Sistemática Em Três Bases de Dados Científicas

Marmitt, Diorge Jônatas; Rempel, Claudete; Goettert, Márcia Inês; Silva, Amanda do Couto e

doi:10.5935/2446-4775.20150011

Cited by 21 publications

(18 citation statements)

References 62 publications

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“…Natural compounds with anti-inflammatory activity add value to herbal products containing them, making these products commercially attractive. The use of natural products with useful pharmacological activities has attracted attention in Brazil, where was created the National List of Medicinal Plants of Interest to the Health Unic System (RENISUS) in 2009, evidencing the importance of medicinal plants in therapeutics (Marmitt, 2015).Concerning the plant safety assessments, cytotoxic assays using bark extracts in fibroblast cells showed no toxicity, with 100% of cell survival and IC 50 higher than 0.2 mg/mL (Politi et al, 2011). However, the type-II arabinogalactan, isolated from E. uchi bark had a cytotoxic effect on HeLa cells, reducing cell viability in 20% over 48 and 72 h in all concentrations tested (5 to 500 µg/mL); at 100 µg/mL, this molecule inhibited HeLa cells proliferation in 25% (Bento et al, 2014).…”

Section: Barksmentioning

confidence: 99%

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

Hyacienth¹,

Ortiz²,

Pereira³

et al. 2019

Afr. J. Pharm. Pharmacol.

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Endopleura uchi (Huber) Cuatrec. is a tree found in the Brazilian Amazon, whose barks are used in folk medicine as an alternative treatment for inflammatory-related diseases. This review, performed using current available international scientific literature, aimed to survey biological activities reported from E. uchi, and describes its phytochemistry. In folk medicine, the barks are used to treat a range of conditions such as intestinal infections, inflammations, diabetes, arthritis, among others; the fruits have some unique nutritional benefits. Phytochemical studies with this plant species indicate the presence of tannins, saponins, and mainly bergenin (a coumarin) in the barks. Among biological activities reported using extracts from the barks are: Inhibition of acetylcholinesterase and butylcholinesterase, bacteriostatic and bactericidal activity, antidiabetic activity through inhibition of αglucosidase, anti-inflammatory and antioxidant activity. Bergenin, the most abundant molecule, has antimicrobial activity mainly against yeasts and anti-inflammatory activity apparently through mitogenactivated protein kinases (MAPK) and muclear factor kappa B (NF-κB) inhibition; its acetylated derivative acetylbergenin has analgesic and more prominent anti-inflammatory activity.

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Section: Barksmentioning

confidence: 99%

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

Hyacienth¹,

Ortiz²,

Pereira³

et al. 2019

Afr. J. Pharm. Pharmacol.

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“…NECC = nº de entrevistados que citaram a categoria de utilização; NECUP = nº de entrevistados que citaram determinada forma de utilização; CUP = índice de concordância de uso principal; FC = fator de correção; CUPc = CUP corrigido. Marmitt et al (2015), ao realizarem levantamento sistemático em três bancos de dados quanto a pesquisas relativas às plantas da Relação Nacional de Plantas Medicinais de Interesse ao Sistema Único de Saúde (RENISUS) no tratamento de infecções/inflamações, apontam o gengibre como a segunda planta mais pesquisada para esta finalidade, ficando atrás apenas do número de estudos sobre o açafrão (Curcuma longa L.), que também pertence à família Zingiberaceae.…”

Section: Fc = Necc/neccmunclassified

Conhecimento e uso do gengibre por familiares de alunos de duas unidades escolares de Alta Floresta/MT

Cardoso

Rossi

Pedri

et al. 2018

G. Sci.

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O gengibre (Zingiber officinale Roscoe) é uma planta utilizada como condimento e fitoterápico. A utilização como fitoterápico segue o conhecimento tradicional, a sabedoria popular, um patrimônio cultural a ser preservado. Este estudo teve por objetivo realizar um levantamento quanto a utilização do gengibre como fitoterápico por familiares de alunos de duas unidades escolares de Alta Floresta, MT. Informações socioeconômicas e relativas à utilização do gengibre foram obtidas por meio de entrevista estruturada e semiestruturada e observação participativa. Os resultados foram avaliados qualitativamente e quantitativamente. Os representantes das famílias entrevistadas são, em sua maioria, do sexo feminino, com idade entre 21 e 40 anos e todos declararam conhecer e utilizar o gengibre como fitoterápico, sendo que informações quanto as formas de uso são obtidas, em 90,2% dos casos, junto ao núcleo familiar. As maiores concordâncias de uso entre os entrevistados foram para o tratamento de gripe e infecção de garganta. Os resultados deste estudo reafirmam a necessidade de pesquisas científicas que registrem a utilização de plantas medicinais, preservando assim o patrimônio cultural e subsidiando pesquisas que visem o registro de fitoterápicos.

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“…The World Health Organization (WHO) estimates that inflammatory diseases are the third largest cause of death in the world, accounting for 3.46 million deaths per year [ 2 , 3 ]. Consistent with these data, the therapeutic class of nonsteroidal anti-inflammatory drugs (NSAIDs) is widely used worldwide [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Campomanesia xanthocarpa Seed Extract Obtained from Supercritical CO2

Petry

Dall'Orsoleta

Scatolin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Campomanesia xanthocarpa is a plant species traditionally used in the treatment of diabetes, fever, hypercholesterolemia, obesity, and urinary tract diseases. The anti-inflammatory effects of C. xanthocarpa leaves in mice were already known. Nevertheless, studies on the anti-inflammatory activity of its seeds are still lacking. The aim of this study was to investigate the anti-inflammatory activity and acute toxicity of C. xanthocarpa seed extract, obtained from supercritical CO2 extraction (SCCO2) at 40°C and 250 bar, in mice. GC/MS analysis revealed that β-caryophyllene is the major compound present in the C. xanthocarpa SCCO2 extract. The extract (60 mg/kg, p.o.) significantly reduced the nociceptive behavior in the second phase of the formalin test and prevented the paw oedema induced by carrageenan up to 6 h after carrageenan injection. The extract (0.1–1 μg/mL) inhibited neutrophils migration induced by LPS from E. coli in vitro. This antichemostatic effect was comparable to the effect of indomethacin. Acute administration (2000 mg/kg, p.o.) of C. xanthocarpa SCCO2 extract caused no mice mortality, demonstrating that the extract is devoid of acute toxicity. These data suggest that C. xanthocarpa seeds present anti-inflammatory activity and represent a source of anti-inflammatory compounds.

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Plantas Medicinais da RENISUS Com Potencial Anti-inflamatório: Revisão Sistemática Em Três Bases de Dados Científicas

Cited by 21 publications

References 62 publications

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

Conhecimento e uso do gengibre por familiares de alunos de duas unidades escolares de Alta Floresta/MT

Anti-Inflammatory Effects of Campomanesia xanthocarpa Seed Extract Obtained from Supercritical CO2

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