Plantar subcutaneous sarcoidosis – a rare form of skin sarcoidosis: unusual plantar aponeurosis location of sarcoidosis as primary manifestation of asymptomatic systemic disease

Janegová, Andrea; Janega, Pavol; Kovac, Ondrej; Dragun, Juraj; Zakutansky, Alexander; Mihalova, Renata; Marinová, Petya; Babál, Pavel

doi:10.1111/cup.12662

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Plantar involvement in sarcoidosis is very rare, and only 3 cases have been reported in the literature. 6–8 In 2 of the reported cases, there were unilateral plantar involvement and they were associated with asymptomatic systemic disease in the form of stage II pulmonary sarcoidosis (nodal and parenchymal lung involvement). 6,7 While in the third case, the plantar lesions were bilateral and were associated with multiple widespread sarcoidal plaques on the arms, forearms, hands, and legs, but there was no pulmonary involvement 8…”

Section: Discussionmentioning

confidence: 99%

“…5 Skin sarcoidosis is one of the great imitators in dermatology. 6 There are “specific” and “nonspecific” findings of cutaneous sarcoidosis, based on the presence or absence of characteristic sarcoid granulomas on histopathological examination. Specific cutaneous sarcoidosis findings include papules, papulonodules, plaques, lupus pernio, and subcutaneous nodules.…”

Section: Discussionmentioning

confidence: 99%

“…1 Plantar involvement in sarcoidosis is very rare, and only 3 cases have been reported in the literature. [6][7][8] In 2 of the reported cases, there were unilateral plantar involvement and they were associated with asymptomatic systemic disease in the form of stage II pulmonary sarcoidosis (nodal and parenchymal lung involvement). 6,7 While in the third case, the…”

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confidence: 99%

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Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Answer

Azzazi¹,

AlOrbani²,

Abdelkader³

2022

The American Journal of Dermatopathology

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ANSWERPlantar sarcoidosis, as a primary manifestation of asymptomatic systemic disease, in the form of stage I pulmonary sarcoidosis (pulmonary lymphadenopathy alone). DISCUSSIONSarcoidosis is a chronic, inflammatory, multisystem, disorder that is characterized by noncaseating granulomas. Sarcoidosis predominantly affects the lungs, but the skin is cited as the second most frequently involved organ, occurring in 25%-30% of patients with systemic sarcoidosis. 1 Females have a higher incidence of sarcoidosis than males. 2 The mean age at diagnosis is 47.31 6 15.46 years. 3 Hypercalcemia and hypercalciuria are reported in the significant number of sarcoidosis patients that was estimated to be 1.8% and 18.8% of patients, respectively, and they were considered as potential biomarkers for disease severity and activity. 4 Skin findings are often the initial presenting sign of sarcoidosis. 5 Skin sarcoidosis is one of the great imitators in dermatology. 6 There are "specific" and "nonspecific" findings of cutaneous sarcoidosis, based on the presence or absence of characteristic sarcoid granulomas on histopathological examination. Specific cutaneous sarcoidosis findings include papules, papulonodules, plaques, lupus pernio, and subcutaneous nodules. Less common cutaneous findings include ichthyosiform, atrophic, ulcerative, mucosal, erythroderma, alopecia, and nail sarcoidosis. 1 Plantar involvement in sarcoidosis is very rare, and only 3 cases have been reported in the literature. [6][7][8] In 2 of the reported cases, there were unilateral plantar involvement and they were associated with asymptomatic systemic disease in the form of stage II pulmonary sarcoidosis (nodal and parenchymal lung involvement). 6,7 While in the third case, the

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Answer

Azzazi¹,

AlOrbani²,

Abdelkader³

2022

The American Journal of Dermatopathology

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“…En la literatura solo se han descrito 2 reportes de casos de sarcoidosis subcutánea plantar como lesión única. En ambos reportes la lesión subcutánea fue la primera manifestación de sarcoidosis sistémica asintomática, encontrándose posteriormente el compromiso pulmonar caracterizado por adenopatías hiliares bilaterales (10,11) . A diferencia de los casos anteriormente publicados, nuestro paciente no presentó compromiso sistémico al diagnóstico o durante el seguimiento, así como tampoco la aparición de nuevas lesiones.…”

Section: Discussionunclassified

Sarcoidosis subcutánea sin compromiso sistémico

et al. 2017

Rev. Hosp. Clín. Univ. Chile (En línea)

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We present the case of a 52 year old woman with a history of bilateral ovarian cancer operated. The patient attended the dermatology unit for a sudden onset of a left plantar nodule of three weeks of evolution, painful on walking, with no other history in particular. At physical examination, the patient presented a surface nodule slightly hyperpigmented, with ill-defined edges, round shape, firm consistency, mobile and painful to compression, one cm of diameter, in the middle third of the left plant. No concomitant scars are seen. Doppler soft tissue ultrasound is requested, showing a granulomatous nodule on the surface of the plantar aponeurosis. The biopsy lesion revealed non-caseating granulomas in cell tissue, PAS and Ziehl-Neelsen staining are negative A left plantar subcutaneous sarcoidosis is diagnosed, systemic involvement is ruled out. Within the first year of follow-up, there are no new lesions or findings compatible with systemic disease.

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Subcutaneous sarcoidosis (Darier–Roussy sarcoidosis) with extensive disease on positron emission tomography: A case report and review of the literature

Youn

Francis

Preston

et al. 2022

Respirology Case Reports

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Cutaneous manifestations of sarcoidosis are common, but subcutaneous nodules are rare, originally described in 1904 by Darier and Roussy and thought to represent isolated skin disease. We present a 61‐year‐old male who presented with 3 months of subcutaneous nodules on the forearms and knees. Biopsy confirmed sarcoidosis. An [F‐18] fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) showed confluent uptake in the skin of forearms and knees, along with thighs and buttocks, mediastinal, hilar and upper abdominal lymph nodes, and multiple bones. He was well and treated with hydroxychloroquine 400 mg/day. The nodules resolved and a repeat FDG PET/CT at 5 months showed a significant decrease in the uptake at all involved sites. Although a PET scan can demonstrate extensive disease in a patient presenting with subcutaneous nodules, the literature suggests prognosis is good and treatment should start simply with the least toxic approach, such as with hydroxychloroquine therapy.

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Plantar subcutaneous sarcoidosis – a rare form of skin sarcoidosis: unusual plantar aponeurosis location of sarcoidosis as primary manifestation of asymptomatic systemic disease

Cited by 5 publications

References 7 publications

Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Answer

Multiple Plantar Swellings as the Presenting Sign of a Systemic Disease: Answer

Sarcoidosis subcutánea sin compromiso sistémico

Subcutaneous sarcoidosis (Darier–Roussy sarcoidosis) with extensive disease on positron emission tomography: A case report and review of the literature

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