Plant-derived synthesis and characterization of gold nanoparticles: Investigation of its antioxidant and anticancer activity against human testicular embryonic carcinoma stem cells

Mobaraki, Fahimeh; Momeni, Mohsen; Yazdi, Mohammad Ehsan Taghavizadeh; Meshkat, Zahra; Toosi, Mahdi Silanian; Hosseini, Seyed Mousalreza

doi:10.1016/j.procbio.2021.09.010

Cited by 45 publications

(16 citation statements)

References 85 publications

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“…In a recent study by Mobaraki et al, 2021, using Achillea biebersteinii flower extract, spherical-shaped (8 nm) gold nanoparticles with anticancer properties against human testicular embryonic carcinoma stem cells were synthesized. The nanoparticles demonstrated dose-dependent cell viability against cancer cells by inducing apoptosis, with half inhibitory concentration (IC50) values of 10 g/mL [192]. In another study, Mousavi-Kouhi et al, 2022, synthesized gold nanoparticles from Verbascum speciosum; the green synthesized AuNPs were about 118 ± 72 nm in size and very effective against the hepatocellular carcinoma cell line (HepG2) and pathogenic bacteria [193].…”

Section: Biological and Theranostic Applicationsmentioning

confidence: 99%

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Muddapur

Alshehri

Ghoneim³

et al. 2022

Molecules

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Bionanotechnology is a branch of science that has revolutionized modern science and technology. Nanomaterials, especially noble metals, have attracted researchers due to their size and application in different branches of sciences that benefit humanity. Metal nanoparticles can be synthesized using green methods, which are good for the environment, economically viable, and facilitate synthesis. Due to their size and form, gold nanoparticles have become significant. Plant materials are of particular interest in the synthesis and manufacture of theranostic gold nanoparticles (NPs), which have been generated using various materials. On the other hand, chemically produced nanoparticles have several drawbacks in terms of cost, toxicity, and effectiveness. A plant-mediated integration of metallic nanoparticles has been developed in the field of nanotechnology to overcome the drawbacks of traditional synthesis, such as physical and synthetic strategies. Nanomaterials′ tunable features make them sophisticated tools in the biomedical platform, especially for developing new diagnostics and therapeutics for malignancy, neurodegenerative, and other chronic disorders. Therefore, this review outlines the theranostic approach, the different plant materials utilized in theranostic applications, and future directions based on current breakthroughs in these fields.

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Section: Biological and Theranostic Applicationsmentioning

confidence: 99%

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Muddapur

Alshehri

Ghoneim³

et al. 2022

Molecules

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“…Another study utilizing bovine serum albuminbound resveratrol NPs in primary ovarian cancer of mice showed that not only the NP-bound resveratrol was easier to work with because of the improved solubility, it had also a greater influence on prevent of tumor growth, compared to pure resveratrol [52]. The anti-cancer effect of gold nanoparticles against breast, testicular, liver, and lung cancer cells has been proven in a concentration-dependent manner [30,[51][52][53][54][55]. In another study, the produced gold nanoparticles provided a safe and great system for the delivery of gapmers in cancerous cells, which meaningfully down-regulated mutant p53 proteins and changed molecular markers related to cell growth and apoptosis [56].…”

Section: Anticancer Properties Of Ncmentioning

confidence: 99%

“…The combination of NCs with gold could enhance the anticancer effects of the NCs along with the biocompatibility of the particles [27]. Due to the potential application of gold in different nanoplatforms for the treatment of cancer, as an active agent or a nanocarrier, it can be a good choice to form nanocomposites with NCs [28][29][30]. The gold inertness and its nontoxic nature are of great use in the design of new active nanomaterials and nanocomposites for biomedical applications [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

Ghorani‐Azam¹,

Mottaghipisheh²,

Amiri³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions. Methods: The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential. Results: The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2). Conclusions: The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Further in vivo investigations is proposed to be designed to assess anti-cancer and safety effects of fabricated nanocomposites.

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“…The resistance of cancer cells to chemical drugs leads to a decrease in the response level of these cells to the drug and consequently the failure of the treatment. Therefore, the development of more effective drugs with few side effects and limitations is very important [5][6][7][8]. Nanotechnology can provide physicians with new strategies for directly targeting cancer cells and increasing drug efficacy [9,10].…”

Section: Introductionmentioning

confidence: 99%

MOF-Mediated Synthesis of CuO/CeO2 Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)

Farhangi

Es‐haghi

Yazdi

et al. 2021

JFB

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A copper oxide/cerium oxide nanocomposite (CuO/CeO2, NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering size analysis (DLS), and zeta potential. The PXRD showed the successful synthesis of the CuO/CeO2 NC, in which the 2theta values of 35.55° (d = 2.52 Å, 100%) and 38.73° (d = 2.32 Å, 96%) revealed the existence of copper (II) oxide. FTIR analysis showed the CeO2, hydroxyl groups, absorbed water, and some residual peaks. The solid phase analysis by FESEM and TEM images showed mean particle sizes of 49.18 ± 24.50 nm and 30.58 ± 26.40 nm, respectively, which were comparable with crystallite size (38.4 nm) obtained from PXRD, but it appears the CuO/CeO2 NC was not evenly distributed and in some areas, showed it was highly agglomerated. The hydrodynamic size (750.5 nm) also showed the agglomeration of the CuO/CeO2 NCs in the solution, which had a negatively charged surface. The CuO/CeO2 NCs showed anti-proliferative activity against human breast cancer cell line (MCF-7) in a dose- and time-dependence way, while affecting normal cells less significantly.

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Plant-derived synthesis and characterization of gold nanoparticles: Investigation of its antioxidant and anticancer activity against human testicular embryonic carcinoma stem cells

Cited by 45 publications

References 85 publications

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

MOF-Mediated Synthesis of CuO/CeO2 Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)

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