Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism

Abstract

The protective effects of selected members from a series of caffeic acid esters and flavonoids were tested in various toxicity paradigms using U937 cells, previously shown to be sensitive to either iron chelators or bona fide radical scavengers or to both classes of compounds. It was found that all the protective polyphenols were active at very low concentrations and that their effects were observed only under those conditions in which iron chelators also afforded protection. Consistently, active polyphenolic compounds, unlike the inactive ones, effectively chelated iron in an in vitro system. It follows that, at least under the experimental conditions utilized in the present study, the most prominent activity of these polyphenolic compounds resides in their ability to chelate iron. Further studies revealed that the protective effects afforded by the caffeic acid esters and flavonoids were largely mediated by the catechol moiety and that the relative biological potency of these compounds was a direct function of their lipophilicity.

Evaluation of Bioactivities and Phenolic Content of Selected Edible Mushrooms in Malaysia

“…It was reported that phenolics' metal chelating power is determined by their chemical structures and the availability of properly oriented functional groups, with six-membered ring complexes exhibited stronger chelating potential than five-membered ring structures [19]. Additionally, the study showed the significant contribution from catechol moiety toward metal-chelating activity [20]. Proteins and polysaccharides had also been implicated in metal-chelating activities [18].…”

Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives

“…Many phenol substances of plant origin or synthetic products and some salicylic acid derivatives as aspirin exhibit certain antioxidant and antiproliferative activities. [3][4][5][6][7][8][9][10][11][12][13][14] Bearing the above in mind, one part of the present research was directed to the microwaveinduced synthesis of some new derivatives of salicylic acid, starting from different amino alcohols, diamines and diols, as well as to the determination of their antioxidant and antiproliferative activities. Microvawe irradiation is an alternative to conventional heating for introducing energy into reactions.…”

Hepatoprotective Effects of Achillea millefolium methanolic extract on carbon tetrachloride induced hepatotoxicity on albino male mice

“…This plant had several poly-phenolic compounds which possess this anti-oxidant activity because; flavonoids of Achillea spp. have one catechol in one of aromatic rings and two hydroxyl groups which are necessary in such activity (Sestili et al, 2002).…”