Plant‐derived peptides for the improvement of Alzheimer's disease: Production, functions, and mechanisms

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset that seriously affects human health. Plant-derived peptides have been found to hinder the development of AD pathologies, which is an excellent candidate for preventing AD. However, due to the excessively complicated pathogenesis of AD and the fact that most studies on the activity of plant-derived peptides are single and not deep enough, which restricted the development and application of plant-derived AD-prevention peptides (PADPs). This review summarized the currently available means of obtaining PADPs, in vitro and in vivo AD-prevention activity validation protocols, molecular pathways of PADPs, the structure-activity relationship between plant-derived peptides and AD-prevention activity, and some perspectives of current advanced technologies. This paper will help to develop the foundation for the production and exploitation of PADPs.

Multi-dimensional deep learning drives efficient discovery of novel neuroprotective peptides from walnut protein isolates

“…Due to the high content of neuroprotection-related amino acids, walnut protein is widely used in the production of neuroprotective peptides. 45 In addition, walnut meal, the by-product of the walnut oil industry, contains a large amount of protein, which is a preferred raw material for the production of neuroprotective peptides. However, it is still a serious challenge to acquire multifunctional neuroprotective peptides needed.…”

Advances on resources, biosynthesis pathway, bioavailability, bioactivity, and application of corylifolinin

“…Neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's (PD), inflict progressive neuronal loss and cognitive deterioration, casting a somber shadow over patients and their families (Lin et al., 2023). The pursuit of effective neuroprotective therapies remains an imposing challenge in contemporary medicine.…”

Effects of an Akt-activating peptide obtained from walnut protein degradation on the prevention of memory impairment in mice

“…13 Walnut peptides have been extensively studied as neuroprotective agents, including new peptide discovery, action mechanisms, and conformational relationships. 14 To date, several walnut peptides with neuroprotective properties have been identified, e.g., RLWPF, VLRLF, LPF, GVYY and APTLW. 15,16 Among them, RLWPF and VLRLF can regulate the intestinal flora of AD model mice, and LPF, GVYY and APTLW have been shown to alleviate neuroinflammation.…”

“…13 Walnut peptides have been extensively studied as neuroprotective agents, including new peptide discovery, action mechanisms, and conformational relationships. 14 To date, several walnut peptides with neuroprotective properties have been identified, e.g. , RLWPF, VLRLF, LPF, GVYY and APTLW.…”