Plant-derived nanovesicles: Current understanding and applications for cancer therapy

Ly, Ngoc Phung; Han, Hwa Seung; Kim, Myungsuk; Park, Jae Hyung; Choi, Ki Young

doi:10.1016/j.bioactmat.2022.10.005

Cited by 41 publications

(31 citation statements)

References 104 publications

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“…15,16 ENVs have gained considerable attention over the past decade as a soluble and bioavailable source of plant bio-actives and as nanocarriers for a variety of molecular cargos. 17 ENVs are non-toxic compared to synthetically derived lipid nanovesicles/particles, lack immunogenicity, and show excellent stability in the gastrointestinal digestion process in vivo . Several ENVs isolated from ginger, broccoli, grapefruit and lemon have been shown to possess the native bio-actives 6-gingerol/6-shogaol, sulforaphane, naringin/naringenin and ascorbic acid, respectively.…”

Section: Introductionmentioning

confidence: 99%

An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine, from edible plants in exosome-like nanovesicles

Kumar,

Kalarikkal,

Bethi

et al. 2023

Green Chem.

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Section: Introductionmentioning

confidence: 99%

An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine, from edible plants in exosome-like nanovesicles

Kumar,

Kalarikkal,

Bethi

et al. 2023

Green Chem.

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“…Administration of the bitter melon-derived EVs (BMDEVs) scavenged the elevated mitochondrial ROS and maintained mitochondrial homeostasis, dominantly preventing radiation-induced cardiomyocyte injury and myocardial fibrosis [ 67 ]. Moreover, these BMDEVs exerted synergistic anti-cancer effects of 5-fluorouracil against oral squamous cell carcinoma [ 68 , 69 ]. In vitro and in vivo analyses further demonstrated the sensitizing effect of BMDEVs on human cancer therapy [ 70 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Zhang

et al. 2023

J Nanobiotechnol

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Background The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as potential mediators involved in cell-cell communication and the exchange of bio-information between species. Recently, several contents have been well identified in PDEVs, including nucleic acids, proteins, lipids, and other active substances. These cargoes carried by PDEVs could be transferred into recipient cells and remarkably influence their biological behaviors associated with human diseases, such as cancers and inflammatory diseases. Main body of the abstract This review summarizes the latest updates regarding PDEVs and focuses on its important role in nanomedicine applications, as well as the potential of PDEVs as drug delivery strategies to develop diagnostic and therapeutic agents for the clinical management of diseases, especially like cancers. Conclusion Considering its unique advantages, especially high stability, intrinsic bioactivity and easy absorption, further elaboration on molecular mechanisms and biological factors driving the function of PDEVs will provide new horizons for the treatment of human disease.

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“…Contrarily, plant-derived compounds are a promising resource for new anticancer drug discovery. About 50% of FDA-approved anticancer drugs are of natural materials [20][21][22][23]. The exploration of potential anticancer agents from natural resources seems to be a charming technique.…”

Section: Introductionmentioning

confidence: 99%

Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species‐dependent pathways in A549 lung cancer cells and in vitro evaluations

Zhang

Ruan

Yang³

et al. 2023

IET Nanobiotechnology

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There is an urgent need for potential pharmaceutics for lung cancer treatment due to the increased number of lung cancer deaths and the resistance of cancer cells to present therapeutics. The present work aims to discover the anticancer potential of the natural compound chaetocin as a therapeutic for lung cancer treatment. Results showed the significance of chaetocin-induced cell growth inhibition by the expression of G 2 /M phase arrest and reactive oxygen species (ROS) dependent apoptosis in A549 lung cancer cells. Results concluded that chaetocin could produce ROS and nuclear damage against A549 lung cancer cells. Interestingly, chaetocin exhibits a significant level of CD47 that downregulates the expression of CD47 at mRNA levels. PBMC biocompatibility study revealed that chaetocin is non-toxic to normal cells. Overall, experimental results suggested that chaetocin induces A549 cell apoptosis, by causing ROS and nuclear damage activation pathways. In the future, chaetocin might be an effective bio-safe anticancer agent for lung cancer treatments.

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Plant-derived nanovesicles: Current understanding and applications for cancer therapy

Cited by 41 publications

References 104 publications

An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine, from edible plants in exosome-like nanovesicles

An eco-friendly one-pot extraction process for curcumin and its bioenhancer, piperine, from edible plants in exosome-like nanovesicles

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species‐dependent pathways in A549 lung cancer cells and in vitro evaluations

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