Plant Cyanogenic Glycosides

Vetter, János

doi:10.1007/978-94-007-6464-4_19

Cited by 25 publications

(31 citation statements)

References 35 publications

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“…Plants use the toxicity of cyanide for protection. More than 3000 species of plants produce cyanogenic glycosides as storage forms of nitrogen and defence compounds (Koukol et al 1962;Cutler & Conn 1982;Selmar et al 1988;Bennet & Wallsgrove 1994;Vetter 2000). While the majority of these species are angiosperms, nearly 300 species of ferns and at least 48 species of gymnosperms synthesize these compounds (Harper et al 1976).…”

Section: Introductionmentioning

confidence: 99%

The β‐cyanoalanine synthase pathway: beyond cyanide detoxification

Machingura

Salomon

Jez

et al. 2016

Plant Cell & Environment

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Production of cyanide through biological and environmental processes requires the detoxification of this metabolic poison. In the 1960s, discovery of the β-cyanoalanine synthase (β-CAS) pathway in cyanogenic plants provided the first insight on cyanide detoxification in nature. Fifty years of investigations firmly established the protective role of the β-CAS pathway in cyanogenic plants and its role in the removal of cyanide produced from ethylene synthesis in plants, but also revealed the importance of this pathway for plant growth and development and the integration of nitrogen and sulfur metabolism. This review describes the β-CAS pathway, its distribution across and within higher plants, and the diverse biological functions of the pathway in cyanide assimilation, plant growth and development, stress tolerance, regulation of cyanide and sulfide signalling, and nitrogen and sulfur metabolism. The collective roles of the β-CAS pathway highlight its potential evolutionary and ecological importance in plants.

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Section: Introductionmentioning

confidence: 99%

The β‐cyanoalanine synthase pathway: beyond cyanide detoxification

Machingura

Salomon

Jez

et al. 2016

Plant Cell & Environment

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“…(almond), Linum usitatissimum (oil flax), Sorghum spp. (sorghum) and Manihot esculenta (cassava)) (Vetter 2000). Approximately 25 cyanogenic glycosides, including amygdalin ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…1), dhurrin, linamarin and linustatin, are found in the edible parts of these plants (Cressey et al 2013). Cyanogenic glycosides exhibit strong antimicrobial properties that inhibit the growth of plant pathogens, while their cytotoxicity also discourages herbivory by some insects and animals (Vetter 2000). Nevertheless, cyanogenic glycoside-accumulating plants are used to produce staple foods by people in developing countries (FAO 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Regardless of their source, the consumption of cyanogenic glycosides by mammals results in the release of hydrogen cyanide, in a process called cyanogenesis (Poulton 1990). Intestinal cyanogenesis largely results from the hydrolytic activity of the intestinal microbiota (Vetter 2000;Montagnac et al 2009). Cyanides are highly reactive carbon-nitrogen functional groups and potent inhibitors of cellular respiration.…”

Section: Introductionmentioning

confidence: 99%

“…The resultant hydrogen cyanide may either be washed away or evaporated from the cassava fermentate, as it is highly volatile. Alternatively, hydrogen cyanide is highly reactive and may be enzymatically converted into ammonia and carbon dioxide by a variety of biocatalytic micro-organisms (Vetter 2000;Dash et al 2009). Unfortunately, the organic acids produced by fermentative micro-organisms may inhibit many of the enzymes that are required to break down cyanogenic glycosides and their metabolic derivatives (Vasconcelos et al 1990).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of amygdalin-degrading Lactobacillus species

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Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

et al. 2021

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Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokines including tumor necrosis factor α (TNFα), tumor necrosis factor β1 (TNFβ1), interleukin 6 (IL-6), and interleukin 4 (IL-4), reactive oxygen species, matrix metalloproteases, and transforming growth factorbeta (TGF-β). Targeting these processes involved in the progression of PF is essential for the treatment of this disease. Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects. In the present study, we reviewed the protective effects and the therapeutic role of various bioactive compounds from plants in PF management.

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Plant Cyanogenic Glycosides

Cited by 25 publications

References 35 publications

The β‐cyanoalanine synthase pathway: beyond cyanide detoxification

The β‐cyanoalanine synthase pathway: beyond cyanide detoxification

Characterization of amygdalin-degrading Lactobacillus species

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

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