Plackett–burman Design as a Tool for Screening and Process Optimization of Rivastigmine-Loaded Lipid Nanocarriers

Abstract

Objective: Plackett-Burman experimental design is used to identify the most important factors early in the experimentation phase when complete knowledge about the system is usually unavailable. The objective of this study was to screen out the most important factors affecting the size and entrapment efficiency of rivastigmine hydrogen tartrate (RHT) nanostructured lipid carriers (NLCs). Methods:The RHT-loaded NLC was prepared by the modified solvent emulsification-diffusion method. The independent variables selected for Plackett-Burman design were drug: lipid ratio, solid lipid/liquid lipid (S/L) ratio, concentration Ryoto sugar ester (%w/v), the concentration of poloxamer 188 (%w/v), sonication time (min), sonication amplitude, and stirring time (h). Results:The R 2 value for the particle size equation was 86.16%. p value was (<0.05) 0.048 in case of sonication time. In case of entrapment efficiency, the R 2 value was 87.12%. The p value (p<0.05) for S/L ratio and the Ryoto sugar (% w/v) was 0.028 and 0.042, respectively. Conclusion:It can be concluded that sonication time has a significant effect on particle size, whereas S/L ratio and Ryoto sugar ester concentration have a significant effect on entrapment efficiency.

Using BCN nanostructure as anode electrode for photoelectrocatalytic degradation of organics: a statistical approach

“…The same approach shows that the initial pH factor has a significant effect and the residence time factor seems to have a little significant effect. Table 4 shows that the effects of residence time and pH are positive and negative, respectively, which are in agreement with the last research studies (Andand et al 2018;Mansouri et al 2018;Xu et al 2018).…”