Placental transfer of anticytoplasmic antibodies in annular erythema of newborns

Miyagawa, Sachiko

doi:10.1001/archderm.117.9.569

Cited by 35 publications

(17 citation statements)

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“…There have also been some reports of resulting atrophy and telangiectasia (9,10). In cases of cutaneous NLE reported fi'om Japan, skin lesions are sitnilar to annular reactive erythemas without an epidermal component (11,12). Case 2 had both kinds of eruptions.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Borrego

Rodríguez

Soler

et al. 1997

Pediatric Dermatology

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Neonatal lupus erythematosus (NLE) is an autoimmune disease whose major findings are skin lesions and congenital heart block. Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases. Mothers of babies with NLE may be asymptomatic initially or may have Sjögren syndrome, lupus erythematosus, overlap syndrome or, uncommonly, leukocytoclastic vasculitis. When evaluating a young woman with a cutaneous leucocytoclastic vasculitis, dermatologists should be aware of the possible presence of antibodies related to NLE. If any patient suffering a disorder related to NLE becomes pregnant, testing for autoantibodies and close obstetric prenatal care with fetal echocardiogram is necessary. In cases of fetal bradycardia, treatment with dexamethasone or betamethasone should be considered, as these drugs are accessible to the fetal circulation.

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Section: Discussionmentioning

confidence: 99%

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Borrego

Rodríguez

Soler

et al. 1997

Pediatric Dermatology

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“…The twins had the same HLA phenotypes and displayed similar courses. In addition to reports of NLE in brothers (13), sisters, and three siblings (14), there have been two other reports of NLE in twins (15,16). However, the reports rarely state whether the twins were identical or fraternal, and HLA typing was rarely conducted (17).…”

Section: Discussionmentioning

confidence: 97%

Neonatal Lupus Erythematosus Occurring in Identical Twins

Shimosegawa

Akasaka

Matsuta

1997

The Journal of Dermatology

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The patients were one-month-old identical twins. Scaly erythema was noted mainly on the trunk, face, and scalp of one twin starting about three weeks after birth and starting about two weeks after birth in the other. The patients' courses were observed without treatment; the eruptions tended to disappear two months after birth. The mother had a past history of transient facial erythema. Both twins and mother were positive for antinuclear antibody, anti-SS-A antibody, and anti-SS-B antibody. The histopathological findings corresponded to those of discoid lupus erythematosus (DLE). The class of HLA typing revealed Cw3 in both twins, which is frequently observed in neonatal lupus erythematosus (NLE), and A24 in the mother, which is frequently observed in mothers of babies with NLE.

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“…The precise role of anti-Ro ⁄ SSA antibody in the development of the cutaneous lesions remains speculative. Strong evidence is available to support the hypothesis that maternal autoantibodies to Ro ⁄ SSA and La ⁄ SSB are directly involved in the pathogenesis of NLE (5,12). Infants with NLE invariably have circulating maternal antibodies against Ro ⁄ SSA, La ⁄ SSB, or both.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Lupus Erythematosus in Identical Twins, Showing Transient Bullous Lesions

Nakajima

Wakiguchi

Kodama

et al. 2011

Pediatric Dermatology

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One of identical twin girls was born with ulcers on her leg, and shortly after birth developed a flaccid blister on the leg. Subepidermal blister with vacuolar degeneration of basal cell layer and the heavy infiltration of mononuclear cells in the upper dermis were observed in the blister lesion. She also had generalized livedo. Her identical twin sister did not exhibit ulcers or blisters, but was born with milia on her limbs. Their mother was found to have lupus erythematosus with positive anti-Ro/SSA antibodies and developed Sjögren syndrome. We emphasize neonatal blistering and congenital milia unique manifestations of neonatal lupus erythematosus.

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Placental transfer of anticytoplasmic antibodies in annular erythema of newborns

Cited by 35 publications

References 0 publications

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Neonatal Lupus Erythematosus Occurring in Identical Twins

Neonatal Lupus Erythematosus in Identical Twins, Showing Transient Bullous Lesions

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