Placental production and foetal utilisation of lactate and pyruvate

Burd, Larry; Jones, Mathew; Simmons, Michael; Makowski, Edgar L.; Meschia, Giacomo; Battaglia, Frederick C.

doi:10.1038/254710a0

Cited by 207 publications

(88 citation statements)

References 10 publications

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“…However, there is strong evidence of net lactate uptake and consumption by ovine and bovine fetuses as a whole [2,6,32,33]. Lactate and other monocarboxylates not only serve the major carbon sources for fatty acid synthesis but also are utilized as a metabolic energy source in various fetal tissues, such as the porcine heart [34], rat brain [35], and ovine liver [36].…”

Section: Subcellular Localization Of Mct1 and Mct4 And The Transfer Omentioning

confidence: 99%

“…In humans and other mammals, the concentration of lactate in the fetal circulation is known to be higher than in the maternal circulation [2][3][4][5][6]. Some researchers consider the major source of lactate in the fetal circulation of humans to be the fetus itself due to the active anaerobic metabolism of fetus-that must be discharged into the maternal circulation [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Some researchers consider the major source of lactate in the fetal circulation of humans to be the fetus itself due to the active anaerobic metabolism of fetus-that must be discharged into the maternal circulation [3][4][5]. On the other hand, fetal tissues of sheep effectively utilize lactate as a metabolic energy source, supplied by placental lactate production or transfer from maternal blood [2,6]. The most likely mechanism of lactate transfer through the placenta involves a specific carrier-mediated system, being coupled with proton transfer [4,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Cellular Expression of the Monocarboxylate Transporter (MCT) Family in the Placenta of Mice

et al. 2010

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Lactate plays an important role as an alternative energy substrate, especially in conditions with a decreased utility of glucose. Proton-coupled monocarboxylate transporters (MCTs) are essential for the transport of lactate, ketone bodies, and other monocarboxylates through the plasma membrane and may contribute to the net transport of lactate through the placental barrier. The present study examined the expression profile and subcellular localization of MCTs in the mouse placenta. An in situ hybridization survey of all MCT subtypes detected intense mRNA expressions of MCT1, MCT4, and MCT9 as well as GLUT1 in the placenta from gestational day 11.5.The expression of MCT mRNAs decreased in the intensity at the end of gestation in contrast to a consistently intense expression of GLUT1 mRNA.Immunohistochemically, MCT1 and MCT4 showed a polarized localization on the maternal side and fetal side of the two cell-layered syncytiotrophoblast, respectively.The membrane-oriented localization of MCTs was supported by the coexistence of CD 147 which recruits MCT to the plasma membrane. However, the subcellular arrangement of MCT1 and MCT4 along the trophoblastic cell membrane was completely opposite of that in the human placenta. Although we cannot exactly explain the reversed localization of MCTs between human and murine placentas, it may be related to differences between humans and mice in the origin of lactate and its utilization by fetuses.3

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Section: Subcellular Localization Of Mct1 and Mct4 And The Transfer Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cellular Expression of the Monocarboxylate Transporter (MCT) Family in the Placenta of Mice

et al. 2010

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“…3), this aspect of the metabolism of the pregnant animal has not been sufficiently investigated to make a quantitative assessment of the importance of placental metabolism for the fetus. However, in the sheep, placental lactate production may make a substantial contribu¬ tion to fetal metabolism (Burd et al, 1975). Also, its metabolism and possible metabolic effects on the fetus may be affected by maternal hormones such as insulin (Freinkel, 1965) and maternal nutritional state (Fain & Scow, 1966 The placenta is also an important site of hormone production for the fetus which is reached by the maternal circulation (Thau & Lauman, 1975).…”

Section: Maternal Metabolism and Fetal Growthmentioning

confidence: 99%

Fetal metabolism and fetal growth

Jones¹

1976

Reproduction

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“…For example, it could serve as fuel for the fetus within the hypoxic environment through glucose generation. 12,13 Hypoxia induces LDH isozyme activity in trophoblasts resulting in higher lactate production. Primary human trophoblast cells demonstrated an increase in LDHA mRNA when exposed to hypoxic conditions confirming LDHA isozyme presence in placental trophoblasts and their response to hypoxia.…”

mentioning

confidence: 99%