2016
DOI: 10.18632/aging.100891
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Abstract: Aging is associated with the onset of several diseases in various organ systems; however, different tissues may age differently, rendering some of them dysfunctional sooner than others. Placental membranes (fetal amniochorionic membranes) protect the fetus throughout pregnancy, but their longevity is limited to the duration of pregnancy. The age-associated dysfunction of these membranes is postulated to trigger parturition. Here, we investigated whether cellular senescence—the loss of cell division potential a… Show more

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Cited by 102 publications
(89 citation statements)
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References 74 publications
(89 reference statements)
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“…A shorter telomere length was found in the chorioamniotic membranes from women who underwent pPROM 63 and in those who underwent spontaneous labor at term 35 . In both scenarios, such a characteristic has been considered a marker of cellular senescence 35, 63 .…”
Section: Resultsmentioning
confidence: 90%
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“…A shorter telomere length was found in the chorioamniotic membranes from women who underwent pPROM 63 and in those who underwent spontaneous labor at term 35 . In both scenarios, such a characteristic has been considered a marker of cellular senescence 35, 63 .…”
Section: Resultsmentioning
confidence: 90%
“…In both scenarios, such a characteristic has been considered a marker of cellular senescence 35, 63 . Relative telomere length was determined using two established methods 34, 45, 46 in the chorioamniotic membranes from the four study groups.…”
Section: Resultsmentioning
confidence: 99%
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“…35 It has also been suggested that labour is associated with senescence-associated changes in the placental membranes mediated by the p38 MAPK pathway, including telomere shortening, p38 MAPK activation and increased expression of p21 and SA-β-galactosidase. 63 OS at term induces DNA damage and telomere shortening, which accelerates telomere-dependent senescence of the foetal membranes, resulting in senescence-associated inflammatory activation that may contribute to parturition. 64 It has long been thought both term and preterm labour have similar processes that occur through a "common pathway".…”
mentioning
confidence: 99%