Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

Soliman, Ahmed; Lacasse, Andrée-Anne; Lanoix, Dave; Sagrillo-Fagundes, Lucas; Boulard, Véronique; Vaillancourt, Cathy

doi:10.1111/jpi.12236

Cited by 93 publications

(79 citation statements)

References 68 publications

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“…Concerning the current research results, we speculate strongly that supplementary antioxidant therapy including Se, Zn, Cu, Mn, ascorbate, GSH, and αtocopherol, as well as melatonin, may be beneficial to such patients during pre-conception and the first-trimester post-conception. 87 Melatonin regulates endometrial morphology and embryo implantation, and is beneficial to a successful pregnancy possibly via F I G U R E 4 Melatonin is a therapeutic agent for endometriosis. 83 It has been further demonstrated that, under specific condition, melatonin treatment could significantly improve fertilization and pregnancy rates.…”

Section: Mel Atonin and Recurrent S P Ontaneous Abortionmentioning

confidence: 99%

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Yang

Zhou

et al. 2018

American J Rep Immunol

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Melatonin is a neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of mammals. Melatonin acts as a broad-spectrum antioxidant, powerful free radical scavenger, anti-inflammatory agent, anticarcinogenic factor, sleep inducer and regulator of the circadian rhythm, and potential immunoregulator. Melatonin and reproductive system are interrelated under both physiological and pathological conditions. Oxidative stress, inflammation, and immune dysregulation are associated with the pathogenesis of the female reproductive system which causes endometriosis (EMS), recurrent spontaneous abortion (RSA), and polycystic ovary syndrome (PCOS). Accumulating studies have indicated that melatonin plays pleiotropic and essential roles in these obstetrical and gynecological disorders and would be a candidate therapeutic drug to regulate inflammation and immune function and protect special cells or organs. Here, we systematically review the pleiotropic roles of melatonin in EMS, RSA, and PCOS to explore its pathological implications and treatment potential.

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Section: Mel Atonin and Recurrent S P Ontaneous Abortionmentioning

confidence: 99%

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Yang

Zhou

et al. 2018

American J Rep Immunol

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“…ASMT is Involved in placental melatonin synthesis (Iwasaki et al, 2005) and melatonin regulates trophoblast differentiation (Soliman et al, 2015). Secretin (SCT) is also localised in this organ (Knox et al, 2011).…”

Section: Genes Involved In Placental Functionmentioning

confidence: 98%

The barrier, airway particle clearance, placental and detoxification functions of autism susceptibility genes

Carter

2016

Neurochemistry International

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“…Simultaneously, melatonin, as a seasonal factor, has been suggested to be involved in a successful pregnancy [62][63][64]. Το be brought to safe conclusions we should carefully consider the pathophysiologic process taking place in preeclampsia (Figure 3).…”

Section: Is a Dysfunction Of The Placental Clock Related To Preeclampmentioning

confidence: 99%

The Biological Clock and Vascular Disease: Application to Pregnancy

Karoutsos¹,

Karoutsos²,

Karoutsou³

2017

J Clin Epigenet

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In mammals, the components of the biological clock function peripherally in a complex network and modulate the transcription of specific target genes and their products, expressed rhythmically in a 24 h rhythm. The central biological clock includes the suprachiasmatic nucleus, which rhythmically 'tunes' peripheral clocks (Figure 1) [1][2][3][4][5][6][7][8].Having the molecular basis of SCN being clarified the so-called core clock genes such as per1-2, cry1-2, bmal1 [9,10] and the demonstration that these genes are rhythmically expressed in peripheral tissues, including the liver, adrenal and pituitary glands [11][12][13], this central clock model is reshaped [14][15][16].Clock/Bmal, formed by the product of the genes circadian locomotor output cycles kaput [Clock] and brain and muscle aryl hydrocarbon receptor nuclear translocator like-Arntl (Bmal) represents the transcription initiator of the feedback loops [17].Clock/Bmal binds to E-box in the promoter regions of target genes Period homolog 1, 2 and 3 genes (Per1, Per2, Per3), Cryptochrome genes (Cry1, Cry2), retinoic acid-related orphan receptor (Rora, Rorb, Rorc) and Rev-Erb nuclear orphan receptor(Rev-Erbα, RevErbβ) to activate their expression [18,19].Transcription of Pers and Crys is initiated during the day, while degradation during the night. PER and CRY proteins enter the nucleus, probably as a multimeric complex (PER/CRY), and inhibit Clock/Bmal-mediated transcription [20,21].As to the role of the PER/CRY complex, Cryptochrome (CRY) is a blue-light sensor, which regulates neuronal firing rate, that is AbstractThe creation of a biological clock adjusted to way of life synchronizers influences the function of peripheral clocks and by extension, all physiological processes as well as secretion of hormones. Further, disturbance of the function of the biological clock exerts a strong impact on the pathogenesis of several disorders, including diabetes mellitus, insomnia, depression, cardiovascular disease and cancer, linking the pathophysiology of many diseases to one molecular mechanism, the 'out of tune clock'.Keywords: Diabetes mellitus; Pathogenesis; Suprachiasmatic nucleus; Cryptochrome circadian entrainment in Drosophila melanogaster [22]. Light activates CRY. When CRY is activated TIM [timeless] degrades, tuning the clock daily. In the absence of cry, the clock can still be activated by light, though the mechanisms are unclear; possibly, there are two types of clock neurons having differential sensitivities to light and temperature [23].With regard to the remainder feedback loop, the ROR/Bmal/RevErb (RBR) frames the original shape [20]. ROR acts as an activator of Bmal and Rev-Erb as an inhibitor which results in tuning of Bmal transcription [24,25]. Suppression of Rev-Erbα expression resulted in elevated Clock mRNA expression consistent with RevErbα's role as a transcriptional repressor, adding a regulation role of the activity of the Bmal1/Clock heterodimer by regulation of the expression of both the Bmal1 and Clock genes directly (Figure 2) [26]...

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Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

Cited by 93 publications

References 68 publications

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

The barrier, airway particle clearance, placental and detoxification functions of autism susceptibility genes

The Biological Clock and Vascular Disease: Application to Pregnancy

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