Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc

Parhi, Lishay; Abed, Jawad; Shhadeh, Amjad; Alon‐Maimon, Tamar; Udi, Shiran; Ben-Arye, Shani Leviatan; Tam, Joseph; Parnas, Oren; Padler‐Karavani, Vered; Goldman‐Wohl, Debra; Mandelboim, Ofer; Bachrach, Gilad

doi:10.1016/j.celrep.2022.110537

Cited by 25 publications

(29 citation statements)

References 71 publications

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“…Fap2 selectively attaches to Gal-GalNAc (Galβ1-3GalNAc) on cancer cells and markedly enhances F. nucleatum presence and abundance in the tumours. A recent study revealed that Fap2 also bind to T cell immunoreceptors with Ig and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT), and impair T and NK cell cytotoxicity, and promote immune cell death, resulting in tumour escape from immunosurveillance [ 52 , 53 ]. Furthermore, Fap2, as a galactose-sensitive adhesion factor, can mediate co-adherence of neighbouring bacteria and increase the diversity and the stability of the developing dental plaque in the oral cavity [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis

Yu¹,

Shi²,

Yuan³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis

Yu¹,

Shi²,

Yuan³

et al. 2023

Heliyon

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“…Unlike other strict anaerobic bacteria, F. nucleatum possess NADH oxidase endowing them with a limited ability to survive in oxygenated environment [ 117 ]. In addition to its implication in periodontal disease [ 118 ], F. nucleatum is capable of systemic dissemination and causing extra-oral infections, such as brain, liver, spleen, and lung abscesses, septicemia related infections, pelvic inflammatory disease, and intrauterine infections [ 119 , 120 , 121 , 122 , 123 , 124 ]. F. nucleatum is equipped with a variety of adhesins that enable it to adhere to various microorganisms.…”

Section: Virulence Factors Of Periodontal Pathogens and Their Associa...mentioning

confidence: 99%

Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis

2023

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Periodontitis is the most common chronic, inflammatory oral disease that affects more than half of the population in the United States. The disease leads to destruction of the tooth-supporting tissue called periodontium, which ultimately results in tooth loss if uncured. The interaction between the periodontal microbiota and the host immune cells result in the induction of a non-protective host immune response that triggers host tissue destruction. Certain pathogens have been implicated periodontal disease formation that is triggered by a plethora of virulence factors. There is a collective evidence on the impact of periodontal disease progression on systemic health. Of particular interest, the role of the virulence factors of the periodontal pathogens in facilitating the evasion of the host immune cells and promotion of carcinogenesis has been the focus of many researchers. The aim of this review is to examine the influence of the periodontal pathogens Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum) in the modulation of the intracellular signaling pathways of the host cells in order to evade the host immune response and interfere with normal host cell death and the role of their virulence factors in this regard.

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“…The specific ligand for Gal/GalNAc seems to be the fusobacterial adhesin Fap2 [ 50 ], an important virulence factor of F. nucleatum , especially for co-aggregation, together with other oral anaerobes such as Porphyromonas gingivalis in the pathogenic mechanism of periodontitis [ 51 ]. Placental tissues are also rich in Gal/GalNAc; thus, the mechanism of F. nucleatum colonization of the placenta in adverse pregnancy outcomes must be due to the same Gal/GaNAc-Fap2 interaction [ 52 ].…”

Section: Oral Anaerobic Bacteria and Cancermentioning

confidence: 99%

Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia

Ursu

Iancu

Porumb-Andrese

et al. 2022

IJMS

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Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients.

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Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc

Cited by 25 publications

References 71 publications

Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis

Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis

Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis

Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia

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