Placental alpha-microglobulin-1 and combined traditional diagnostic test: a cost-benefit analysis

Accuracy and response time of dual biomarker model of insulin‐like growth factor binding protein‐1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha‐microglobulin‐1 test in diagnosis of premature rupture of membranes

“…Previous studies have shown that the PAMG‐1 test has high diagnostic accuracy and cost–benefit, although the accuracy is not 100% . However, AFP alone is a useful marker for PROM although there is concern for the overlap in its concentrations between women with and without ROM .…”

Diagnosis of rupture of membranes: AmniSure, clinical assessment, and the Food and Drug Administration warning

“…AmniSure has been reported to be cost-effective in a teaching hospital environment on the basis of provider time and equipment utilization. 12,13 Avoiding a provideradministered physical examination has Original Research the potential to reduce the amount of time a woman spends being evaluated and eliminate an invasive sterile speculum, thereby improving the patient experience. 14,15 Finally, minimizing the number of examinations required by a provider reduces the workload of providers, the primary cause of provider burnout.…”

A high concentration of fetal fibronectin in cervical secretions increases the risk of intra-amniotic infection and inflammation in patients with preterm labor and intact membranes

“…Fetal fibronectin is considered a biochemical marker of membrane/decidual activation, as is the increased expression of insulin growth factor binding protein (IGFBP)-1 [39][40][41][42][43][44][45][46][47][48][49][50][51][52] or α−1 microglobulin (also measurable with a PMG test in cervical and vaginal fluid) [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67]. Membrane/decidual activation can be induced by the physiologic events that lead to spontaneous labor and delivery, or by pathologic insults, such as infection or inflammation [1,2,[5][6][7][8].…”