Current Opinion in Hematology volume 17, issue 4, P313-318 2010 DOI: 10.1097/moh.0b013e328339f295 View full text
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Lydia K Lee, Masaya Ueno, Ben Van Handel, Hanna KA Mikkola

Abstract: AbstractPurpose of review-The lifelong stream of all blood cells originates from the pool of hematopoietic stem cells (HSC) generated during embryogenesis. Given that the placenta has been recently unveiled as a major hematopoietic organ that supports HSC development, the purpose of this review is to present current advances in defining the origin and regulation of placental HSCs.Recent findings-The mouse placenta has been shown to have the potential to generate multipotential myelo-lymphoid hematopoietic ste…

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