Place du vert d’indocyanine couplée à l’imagerie par fluorescence dans la recherche du ganglion sentinelle du cancer du sein

Vermersch, C.; Raia-Barjat, Tiphaïne; Perrot, Marianne; Lima, Suzanne; Chauleur, Céline

doi:10.1016/j.bulcan.2016.01.015

Cited by 6 publications

(1 citation statement)

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“…The fluorescent tracer indocyanine green (ICG) has been used in clinical practice for the past 40 years 5 . Several feasibility studies have shown it to be a reliable and relevant marker of SLN in patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Randomized comparison between indocyanine green fluorescence plus 99mtechnetium and 99mtechnetium alone methods for sentinel lymph node biopsy in breast cancer

Vermersch

Raia-Barjat

Chapelle

et al. 2019

Sci Rep

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Use of both patent blue and a radioisotope to locate, and reduce the risk of sentinel lymph node (SLN) detection failure in breast cancer is recommended, but drawbacks commonly lead to using only a radioisotope. An alternative method would therefore be valuable. This randomized, controlled study in 99 patients compared SLN detection using 99m technetium (Tc) alone versus Tc combined with indocyanine green (ICG). The primary endpoint was the SLN identification rate. The primary outcome measure was the number of patients with <2 SLN detected. One SLN was detected in 44.0% of patients in the dual detection group and 40.8% in the 99m Tc alone group (RR = 1.08 (95% CI 0.68; 1.72), p = 0.84). A mean (±SD) of 2.14 ± 1.23 SLN were identified in the dual detection group vs . 1.77 ± 0.85 using Tc alone ( p = 0.09). Eight-five (78.7%) SLN were both ICG+ and TC+, 15 (13.9%) ICG+ and Tc−, and 7 (6.5%) ICG− and Tc+. SLN detected were ICG-positive in 92.6% of patients and 99m Tc-positive in 85.2% with. No adverse event related to ICG injection was recorded. Dual detection of SLN using ICG and radioisotope is reliable and sensitive but was not superior to isotope alone in successfully locating SLN in our pilot randomized trial.

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Section: Introductionmentioning

confidence: 99%