Place and Response Learning of Rats in a Morris Water Maze: Differential Effects of Fimbria Fornix and Medial Prefrontal Cortex Lesions

Bruin, Jan; Moita, Marta A.; Brabander, Hannie M. de; Joosten, R

doi:10.1006/nlme.2000.3962

Cited by 119 publications

(76 citation statements)

References 34 publications

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“…In fact, a lack of effect of PFC manipulation has been reported in rats both in the Morris water maze (de Bruin et al, 1994) as well as in an object displacement task similar to the one used in the present study (Poucet, 1989). These discrepancies have been explained on the basis of procedural differences involving short vs long-term memory (de Bruin et al, 1994(de Bruin et al, , 2001. While the present experiments were not designed to address these issues, a deficit in short-term memory independent of the kind of information would have been expected to also impair novel object discrimination in session 6 and this was not the case.…”

Section: Prefrontal Cortex Dopamine In Spatial Learningmentioning

confidence: 51%

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D1 and D2 Receptor Antagonist Injections in the Prefrontal Cortex Selectively Impair Spatial Learning in Mice

Rinaldi

Mandillo

Oliverio

et al. 2006

Neuropsychopharmacol

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The prefrontal cortex (PFC) is a cortical area involved in selecting and retaining information to produce complex behaviors. Within the PFC, the dopaminergic system plays an important role in information processing. Thus, the objective of this study was to test whether bilateral administration of the D1 and D2 receptor antagonists in the prelimbic region of the PFC influenced the performance of mice in a non-associative spatial learning task. CD1 mice were bilaterally microinjected in the PFC with either the D1 receptor antagonist, SCH23390 (SCH 6.25; 12.5; 50 ng), or the D2 receptor antagonist, sulpiride (SULP 12.5; 50; 100 ng) and placed into an open field containing five different objects. After three sessions of habituation two objects were repositioned (spatial change) and in the subsequent session one of the objects was substituted (non-spatial change). No significant alteration was observed in the habituation pattern of the animals after D1 or D2 receptor blockade. When two of the objects were displaced, control mice explored the displaced objects far more than the non-displaced ones, while mice treated with SCH or SULP spent a comparable amount of time re-exploring the two object categories. Conversely, DA antagonists had no effects on the discrimination of the new object. Thus, the administration of both SCH and SULP selectively impaired the ability of mice to discriminate a spatial change, without affecting any other behavioral parameter. These findings could provide a model to study the role of the PFC dopaminergic system in spatial learning and to study the neural mechanisms underlying cognitive and attention deficits often observed in psychiatric disorders.

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Section: Prefrontal Cortex Dopamine In Spatial Learningmentioning

confidence: 51%

“…It should be noted, however, that the literature is not always consistent in indicating a role for this structure in spatial information processing (Poucet, 1989;de Bruin et al, 1994de Bruin et al, , 2001Delatour and Gisquet-Verrier, 1996;Granon et al, 1996;Lacroix et al, 2002).…”

Section: Introductionmentioning

confidence: 97%

D1 and D2 Receptor Antagonist Injections in the Prefrontal Cortex Selectively Impair Spatial Learning in Mice

Rinaldi

Mandillo

Oliverio

et al. 2006

Neuropsychopharmacol

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“…Therefore, it is unlikely that the transient acquisition deficit of MD-rats was due to a deficit in learning of the task or in using spatial cues, but was initially due to perseveration of an ineffective strategy (i.e., thigmotaxis) and an impaired ability to switch to other strategies. In this respect, it might also be of interest to examine the effects of RE-and MD-lesions, using the egocentric response-learning version of the watermaze task (e.g., De Bruin et al 2001).…”

Section: Effects Of Hippocampal Versus Thalamic Lesionsmentioning

confidence: 99%

“…Kolb et al (1982Kolb et al ( , 1983 showed that mPFC-lesioned rats can fail to learn a watermaze task. Later studies revealed that mPFC lesions can also cause no impairment in spatial navigation, but rather result in a deficit of behavioural flexibility (De Bruin et al 1994, 2001Lacroix et al 2002). In various tests, it has been shown that destruction or inactivation of mPFC does not affect learning and memory per se, but impairs the animals' ability to shift strategy, or rule out inappropriate strategies when task demands are changed or environmental conditions are altered (Ragozzino et al 1999a, b;Delatour and Gisquet-Verrier 2000;Dias and Aggleton 2000;Lacroix et al 2002;Sullivan and Gratton 2002;Passetti et al 2002;Ragozzino et al 2003;Ragozzino 2007).…”

Section: Effects Of Hippocampal Versus Thalamic Lesionsmentioning

confidence: 99%

“…Therefore, we used a conventional (reference memory) watermaze task, known to be sensitive to dysfunction of both the hippocampal and prefrontal systems, with each system mediating different aspects of watermaze learning. Whereas the hippocampal formation is engaged in the spatial aspects of learning and memory, the role of mPFC in this task appears to involve behavioural flexibility and the execution of spatial strategies, rather than encoding or storage of spatial information (De Bruin et al 1994;Ragozzino et al 1999a, b;De Bruin et al 2001;Lacroix et al 2002;Passetti et al 2002;Ragozzino et al 2003). Therefore, a RE lesion, that could affect both the hippocampal and mPFC memory systems, might be expected to cause a mixture of hippocampal (spatial learning/memory) and mPFC (behavioural flexibility/strategy learning) related impairments.…”

Section: Introductionmentioning

confidence: 99%

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Neurotoxic lesions of the thalamic reuniens or mediodorsal nucleus in rats affect non-mnemonic aspects of watermaze learning

Weel¹,

Morris

2009

Brain Struct Funct

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Rats with bilateral neurotoxic reuniens (RE), mediodorsal (MD), hippocampal (HIPP) or sham (SH) lesions were tested in a standard watermaze task, together with unoperated rats. RE-rats and SH-controls readily learned to swim directly to a hidden platform. In contrast, MD-rats displayed a transient deficit characterized initially by thigmotaxis. Like in previous studies, HIPP-rats had long latencies throughout training and displayed more random swims than the other groups. In a memory probe test with the platform removed, SH-and RE-rats approached the correct location relatively directly but, whereas SH-controls persistently searched in the training quadrant, RE-rats switched to searching all over the pool. The MDgroup swam in loops to the platform, but then displayed persistent searching in the training quadrant. The HIPPgroup performed at chance. These distinct patterns indicate that, although their search strategies were different, REand MD-rats had acquired sufficient knowledge about the platform location and could recall information in the probe test. All groups performed well in a subsequent cue test with a visible platform, with RE-rats initially escaping faster than the SH-and HIPP-groups, and MD-rats improving from an initially poorer level of performance to control level. This indicates that there were no sensorimotor or motivational deficits associated with any of the lesions. In conclusion, while the RE and MD nuclei seem not to be critical for the learning and memory of a standard watermaze task, they may contribute to non-mnemonic strategy shifting when animals are challenged in ways that do not occur during training.

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Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex

Oda

Tsuneoka

Yoshida

et al. 2018

J of Comparative Neurology

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The medial prefrontal cortex (mPFC) has been considered to participate in many higher cognitive functions, such as memory formation and spatial navigation. These cognitive functions are modulated by cholinergic afferents via muscarinic acetylcholine receptors. Previous pharmacological studies have strongly suggested that the M1 receptor (M1R) is the most important subtype among muscarinic receptors to perform these cognitive functions. Actually, M1R is abundant in mPFC. However, the proportion of somata containing M1R among cortical cellular types, and the precise intracellular localization of M1R remain unclear. In this study, to clarify the precise immunolocalization of M1R in rat mPFC, we examined three major cellular types, pyramidal neurons, inhibitory neurons, and astrocytes. M1R immunopositivity signals were found in the majority of the somata of both pyramidal neurons and inhibitory neurons. In pyramidal neurons, strong M1R immunopositivity signals were usually found throughout their somata and dendrites including spines. On the other hand, the signal strength of M1R immunopositivity in the somata of inhibitory neurons significantly varied. Some neurons showed strong signals. Whereas about 40% of GAD67‐immunopositive neurons and 30% of parvalbumin‐immunopositive neurons (PV neurons) showed only weak signals. In PV neurons, M1R immunopositivity signals were preferentially distributed in somata. Furthermore, we found that many astrocytes showed substantial M1R immunopositivity signals. These signals were also mainly distributed in their somata. Thus, the distribution pattern of M1R markedly differs between cellular types. This difference might underlie the cholinergic modulation of higher cognitive functions subserved by mPFC.

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Place and Response Learning of Rats in a Morris Water Maze: Differential Effects of Fimbria Fornix and Medial Prefrontal Cortex Lesions

Cited by 119 publications

References 34 publications

D1 and D2 Receptor Antagonist Injections in the Prefrontal Cortex Selectively Impair Spatial Learning in Mice

D1 and D2 Receptor Antagonist Injections in the Prefrontal Cortex Selectively Impair Spatial Learning in Mice

Neurotoxic lesions of the thalamic reuniens or mediodorsal nucleus in rats affect non-mnemonic aspects of watermaze learning

Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex

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