PLA nanoparticles loaded with thymol to improve its incorporation into gelatine films

Sáez‐Orviz, Sara; Marcet, Ismael; Weng, Shihan; Rendueles, Manuel; Dı́az, Mario

doi:10.1016/j.jfoodeng.2019.109751

Cited by 26 publications

(10 citation statements)

References 29 publications

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“…To summarize, TH was successfully encapsulated into PLGA NPs with suitable particle diameters and good stability. Moreover, other authors have developed different types of NPs for TH encapsulation such as PLA or chitosan NPs obtaining lower stability values (around 60%) [ 28 ]. Lipid NPs containing thymol have also been developed with a negative surface charge confirming their anti-inflammatory properties but they were assessed for psoriasis treatment [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…In order to overcome TH physicochemical drawbacks, several authors have attempted to encapsulate it into several delivery platforms such as cyclodextrins [ 26 , 27 ], and lipid nanoparticles [ 25 ] among others [ 28 ]. Moreover, in order to improve active compounds bioavailability after topical administration, polymeric nanoparticles (NPs) constitute excellent potential candidates.…”

Section: Introductionmentioning

confidence: 99%

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Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment

et al. 2021

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The present work is focused on the development of novel surface-functionalized poly(lactic-co-glycolic acid) nanoparticles loaded with thymol (TH-NPs) for topical administration enhancing thymol anti-inflammatory, antioxidant and wound healing activities against acne. TH-NPs were prepared by solvent evaporation method using different surface functionalization strategies and obtaining suitable physicochemical parameters and a good short-term stability at 4 °C. Moreover, TH-NPs skin penetration and antioxidant activity were assessed in ex vivo pig skin models. Skin penetration of TH-NPs followed the follicular route, independently of the surface charge and they were able to enhance antioxidant capacity. Furthermore, antimicrobial activity against Cutibacterium acnes was evaluated in vitro by the suspension test showing improved antibacterial performance. Using human keratinocyte cells (HaCat), cytotoxicity, cellular uptake, antioxidant, anti-inflammatory and wound healing activities were studied. TH-NPs were non-toxic and efficiently internalized inside the cells. In addition, TH-NPs displayed significant anti-inflammatory, antioxidant and wound healing activities, which were highly influenced by TH-NPs surface modifications. Moreover, a synergic activity between TH-NPs and their surface functionalization was demonstrated. To conclude, surface-modified TH-NPs had proven to be suitable to be used as anti-inflammatory, antioxidant and wound healing agents, constituting a promising therapy for treating acne infection and associated inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment

et al. 2021

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“…The amount of the compound released at 40 • C after 24 h was considered the entire active ingredient contained in the films. A similar procedure has been used by other authors in the literature [62,63]. The amount of the active compounds released into the methanol was compared with the amount incorporated into the film-forming solution to calculate the amount loss during the drying step.…”

Section: Quantification Of the Active Ingredients In The Pla Matrixmentioning

confidence: 99%

Development of Bio-Composites with Enhanced Antioxidant Activity Based on Poly(lactic acid) with Thymol, Carvacrol, Limonene, or Cinnamaldehyde for Active Food Packaging

et al. 2021

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The new trend in food packaging films is to use biodegradable or bio-based polymers, such as poly(lactic acid), PLA with additives such as thymol, carvacrol, limonene or cinnamaldehyde coming from natural resources (i.e., thyme, oregano, citrus fruits and cinnamon) in order to extent foodstuff shelf-life and improve consumers’ safety. Single, triple and quadruple blends of these active compounds in PLA were prepared and studied using the solvent-casting technique. The successful incorporation of the active ingredients into the polymer matrix was verified by FTIR spectroscopy. XRD and DSC data revealed that the crystallinity of PLA was not significantly affected. However, the Tg of the polymer decreased, verifying the plasticization effect of all additives. Multicomponent mixtures resulted in more intense plasticization. Cinnamaldehyde was found to play a catalytic role in the thermal degradation of PLA shifting curves to slightly lower temperatures. Release of thymol or carvacrol from the composites takes place at low rates at temperatures below 100 °C. A combined diffusion-model was found to simulate the experimental release profiles very well. Higher antioxidant activity was noticed when carvacrol was added, followed by thymol and then cinnamaldehyde and limonene. From the triple-component composites, higher antioxidant activity measured in the materials with thymol, carvacrol and cinnamaldehyde.

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“…Besides, in a study conducted by Sáez‐Orviz et al . ( 2020 ), the gelatine films with PLA‐thymol nanoparticles showed high transparency, a homogeneous microstructure and antimicrobial properties. In addition to the combination of the above gelatin and antibacterial agents, Eun and other researchers used fish by‐products to produce gelatin peptides with antioxidant and antibacterial functions, and applied them to carbonated beverages.…”

Section: Protein‐based Antibacterial Materials and Application In Foodmentioning

confidence: 92%

Protein‐based natural antibacterial materials and their applications in food preservation

Zhen

Wang

et al. 2021

Microbial Biotechnology

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Summary Plastics materials used for food packaging are recalcitrant, leading to a growing global environmental problem, which arouses the attention of environmental protection departments in many countries. Therefore, to meet the increasing demand for sustainable and environment‐friendly consumer products, it is necessary for the food industry to develop natural antibacterial materials for food preservation. This review summarizes the common biodegradable natural antimicrobial agents and their applications in food preservation; as well as an overview of five commonly used biodegradable protein‐based polymers, such as zein, soy protein isolate, gelatin and whey protein, with special emphasis on the advantages of protein‐based biopolymers and their applications in food packaging industry.

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PLA nanoparticles loaded with thymol to improve its incorporation into gelatine films

Cited by 26 publications

References 29 publications

Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment

Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment

Development of Bio-Composites with Enhanced Antioxidant Activity Based on Poly(lactic acid) with Thymol, Carvacrol, Limonene, or Cinnamaldehyde for Active Food Packaging

Protein‐based natural antibacterial materials and their applications in food preservation

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