2017
DOI: 10.18632/aging.101299 View full text |Buy / Rent full text
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Abstract: Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study investigated the role of the PKC pathway in oxPOS-induced RPE multinucleation using ARPE19 cells. oxPOS treatment promoted PKC activity and upregulated the mRNA expression of PKC α, δ, ζ, ι and μ. In… Show more

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“…This cell death stimulation could be additionally enforced by the downexpression of CDKN2D and the overexpression of CDKN1B. [93,[126][127][128][129][130][131][132][133][134] ZINC FINGERS TRANSCRIPTION FACTORS…”
Section: Retinoic Acid Cycle (Rdh5 Mkv)mentioning
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“…This cell death stimulation could be additionally enforced by the downexpression of CDKN2D and the overexpression of CDKN1B. [93,[126][127][128][129][130][131][132][133][134] ZINC FINGERS TRANSCRIPTION FACTORS…”
Section: Retinoic Acid Cycle (Rdh5 Mkv)mentioning
“…Incubation with OxPOS also led to activation of protein kinase C (PKC) isoforms and PKC-dependent upregulation of the Cdk inhibitor p27kip. Suppression of cell proliferation was observed with multinucleate RPE [64], of which the latter is associated with pathology in the retina. Moreover, OxPOS induced expression of the senescence marker β-galactosidase.…”
Section: Discussionmentioning
“…Cancers, such as gliomas [ 73 , 74 , 75 ] and colon cancer [ 76 ], present an upregulation of the canonical WNT/β-catenin pathway associated with a decrease of PPARγ expression [ 77 ]. The process of fibrosis exhibits the same mechanism [ 78 , 79 , 80 ]. Neurodegenerative diseases are classified in two categories [ 34 ], i.e., diseases that present a downregulation of the canonical WNT/β-catenin pathway and an upregulation of PPARγ, such as Alzheimer’s disease [ 81 , 82 , 83 ], and diseases with an upregulation of the canonical WNT/β-catenin pathway whereas PPARγ is decreased, such as exudative age related macular degeneration [ 84 , 85 ], amyotrophic lateral sclerosis [ 86 ], and multiple sclerosis [ 18 ].…”
Section: Crosstalk Between Pparγ and Canonical Wnt/β-catenin Pathwmentioning