Pityriasis rotunda. A cutaneous marker of hepatocellular carcinoma in South African blacks

DiBisceglie, Adrian M.; Hodkinson, H J; Berkowitz, I; Kew, M. C.

doi:10.1001/archderm.122.7.802

Cited by 27 publications

(11 citation statements)

References 7 publications

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“…There is however little practical purpose in distinguishing between the two types since both may be found in different parts of the same tumor and the clinical course are similar. Skin features documented with PLCC include cutaneous porphyria [7,8], pityriasis rotunda [9,10], papules and nodules to the skin from metastasis [11,12]. Some features found in this study point to possible underlying or background liver cirrhosis (LC) before the transformation to malignancy.…”

Section: Discussionmentioning

confidence: 72%

Cutaneous features seen in primary liver cell (Hepatocellular) carcinoma patients at a University Teaching Hospital in Nigeria

George¹,

Otegbayo²,

Ogunbiyi³

et al. 2008

African Journal of Health Sciences

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SUMMARYPrimary liver cell carcinoma (PLCC), predominantly hepatocellular carcinoma is a killer. In the southwestern region of Nigeria it occupies the second position, behind prostate cancer in males. Females account for about a third of diagnosed cases. Children are not spared. Over 80 % of PLCC cases present to the hospital at an advanced stage in Nigeria and some die within weeks of admission to the wards. A prospective hospital based study was carried out to determine muco-cutaneoeus features associated with the entity as a possible aid to diagnosis cutaneous features being considered a cheap tool that can help diagnosis in a developing country-at an affordable cost. 80 of 84 patients seen during the study period had data that were adequate for analysis. The age range was 18-76 years with a mean of 56.2 years. The male female ratio was 17:3 indicating that males remain the more affected gender. No skin feature was found to be specific to PLCC. Jaundice (63.75 %), pallor 43.75 %), peripheral oedema (32.50 %), palmoplantar macular hyperpigmentation (47.5 %/25.0% -plantar /palmar) however were the common features documented in the study. Moderate to severe pityriasis versicolor was found in 18.75 % of cases. 61.25 % had core temperature less than 36 0 C. Amongst non-cutaneous features found on examination, right sided upper abdominal pain/discomfort and swelling were common. While none of the features documented in this study are specific to PLCC (and most are likely related to underlying liver cirrhosis) it may be helpful to realize that Jaundice and marked palmoplantar macular pigmentation, the complaint of pain /mass, and the presence of a tender nodular mass in the right hypochondrium should make one to consider the localization of the disease to the liver. Pain/tenderness in the right hypochondrium suggest rapid growth of the liver from increased mitosis in the hepatocytes and a stretching of the liver capsule. Metastasis to the liver accounts for a very small percentage in Nigerians. A nodular liver is thus likely to be from a primary liver pathology.

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Section: Discussionmentioning

confidence: 72%

Cutaneous features seen in primary liver cell (Hepatocellular) carcinoma patients at a University Teaching Hospital in Nigeria

George¹,

Otegbayo²,

Ogunbiyi³

et al. 2008

African Journal of Health Sciences

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“…Type II occurs in younger individuals and is not associated with malignancies. There is no specific treatment for PR, lesions resolve after treating the underlying condition [14,15]. Pemphigus foliaceus (PF) is a superficial blistering lesion with bullae formation.…”

mentioning

confidence: 99%

Cutaneous manifestations of hepatocellular cancer (HCC)

Al-Khazraji

2016

Expert Review of Gastroenterology & Hepatology

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“…It is characterized by multiple, round or oval, sharply demarcated, scaling patches. Although in previous reports this disease was considered to be a form of acquired ichthyosis 4,5 or the expression of a systemic disorder, 6–8 the clinical phenotype and histology of the eruption resemble those of autosomal dominant ichthyosis vulgaris 1,2 . In order to characterize the keratinization disorders overlying PR and to assess their aetiology, we examined the expression patterns of marker proteins in epidermal differentiation.…”

mentioning

confidence: 99%