1982
DOI: 10.1001/archderm.118.3.186
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Pityriasis rosea-like rash from captopril

Abstract: Captopril, an orally active dipeptidylcarboxypeptidase inhibitor, is a promising new antihypertensive agent. Cutaneous reactions, including (rarely) a pityriasis rosea-like eruption, are frequently associated with this therapy. Two new cases of a pityriasis rosea-like captopril-induced eruption support a pharmacologic mechanism for the eruption, since it resolved after the dosage of captopril was lowered in one patient and continued when the dosage of captopril remained unchanged in the other patient. However,… Show more

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Cited by 16 publications
(9 citation statements)
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“…Ampicillin and systemic corticosteroids have been found to exacerbate PR [11]. Isolated cases of pityriasis rosea like rashes have also been reported following administration of captopril, metronidazole and omeprazole [13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Ampicillin and systemic corticosteroids have been found to exacerbate PR [11]. Isolated cases of pityriasis rosea like rashes have also been reported following administration of captopril, metronidazole and omeprazole [13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…An infectious etiology (particularly viral) or an immunologic one has been suggested [4]. , Eruptions similar to pityriasis rosea have been observed in patients treated with var ious drugs, suggesting a possible etiologic link.…”
Section: Commentmentioning
confidence: 99%
“…Medications that have been reported to produce eruptions like pityriasis rosea in clude arsenics, bismuth compounds, gold compounds, tripelennamine hydrochloride, methoxypromazine, barbiturates, clonidine. metronidazole, and captopril [4],…”
Section: Commentmentioning
confidence: 99%
“…Pityriasis rosea has been associated with the wearing of new garments, pregnancy and more recently a possible infectious agent [2]. A few pharmacologic agents have also been incriminated in the genesis of pityriasis-rosea-like eruption: arsenicals, bismuth compounds, gold compounds, tripelennamine hydrochloride, methoxypromazine, barbiturates, clonidine, captopril, omeprazole, isotretinoin and terbinafine [3, 4, 5, 6, 7]. The time from the start of treatment to the onset of the eruption is very heterogeneous (4 days to 8 months), and the delay for disappearance of cutaneous lesions is about 1 month but is not often specified.…”
Section: Introductionmentioning
confidence: 99%
“…The time from the start of treatment to the onset of the eruption is very heterogeneous (4 days to 8 months), and the delay for disappearance of cutaneous lesions is about 1 month but is not often specified. It is very interesting to note that the eruption has been described to decrease with a reduction of the drug dose suggesting that the rash might be dose related ratherthan occurring due to an allergic mechanism, especially because recurrence of the eruption at the reintroduction of the suspected drug is inconstant [3, 5]. Moreover, the results of patch tests and prick tests in 2 patients with pityriasis rosea induced by gold compounds were negative at 30 min, and the intradermal tests at 30 min and 48 h and lymphocyte proliferation to gold in these patients were comparable with that in control subjects suggesting that delayed-type hypersensitivity does not play a part in these cutaneous reactions [5].…”
Section: Introductionmentioning
confidence: 99%