Pioglitazone Attenuates Ischemia/Reperfusion–Induced Liver Injury in Rats

Somi, Mohammad Hossein; Hajipour, Babak; Asl, Naser Ahmadi; Estakhri, Rasoul; Azar, Alireza Nour; Zade, M.N.; Haghjou, A Ghorbani; Vatankhah, Amir Mansour

doi:10.1016/j.transproceed.2009.09.075

Cited by 34 publications

(39 citation statements)

References 31 publications

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“…Then, tissue homogenate were used for determination of lipid peroxides (MDA) and activities of SOD, GPx and catalase. 26 …”

Section: Hypoxia Induction Environmental Chambermentioning

confidence: 99%

“…Glutathione peroxidase (GPx) activity was measured according to Paglia and Valentine using Randox (United Kingdom). Tissue superoxide dismutase (SOD) was assayed by a spectrophotometric method based on the inhibition of a superoxide-induced reduced nicotinamide adenine dinucleotide (NADH) oxidation according to Paoletti et al 26 Statistical analysis Data were statistically analyzed using One way analysis of variance (ANOVA) followed by Tukey's test. The significant level was set at p<0.05.…”

Section: Glutathione Peroxidase and Superoxide Dismutase Assessment Imentioning

confidence: 99%

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Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Omrani¹,

Alipour²,

Mohaddes³

2015

Adv Pharm Bull

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“…Then, tissue homogenate were used for determination of lipid peroxides (MDA) and activities of SOD, GPx and catalase. 26 …”

Section: Hypoxia Induction Environmental Chambermentioning

confidence: 99%

Section: Glutathione Peroxidase and Superoxide Dismutase Assessment Imentioning

confidence: 99%

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Omrani¹,

Alipour²,

Mohaddes³

2015

Adv Pharm Bull

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“…The homogenates were centrifuged at 1000 rpm for 1 min at 4 °C. The tissue homogenate was then stored at -20 °C for glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) measurements (19,25).…”

Section: Preparing Garlic Homogenatementioning

confidence: 99%

“…SOD activity was measured by the degree of inhibition of this reaction. After calculating the percent of inhibition by using the related formula, SOD activity value was calculated by comparing with the standard curve and was expressed as U/g hemoglobin (Hb) in blood and U/mg protein in tissue (19,25).…”

Section: Determination Of Antioxidant Enzymesmentioning

confidence: 99%

“…In the presence of glutathione reductase (at a concentration ≥ 0.5 units/L) and 0.28 mmol/L of NADPH, oxidized glutathione is immediately converted to the reduced form with concomitant oxidation of NADPH to NADP + . The decrease in absorbance at 340 nm (37 °C) was measured using a spectrophotometer (Pharmacia Biotech., Cambridge, England), and then GPx concentration was calculated by the related formula (19,25).…”

Section: Determination Of Antioxidant Enzymesmentioning

confidence: 99%

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Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Naderi

Mohaddes

Mohammadi

et al. 2015

Acta Physiologica Hungarica

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Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects of garlic (Allium sativum) were investigated in the blood and heart of streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats were randomly divided into four groups: control, garlic, diabetic, and diabetic+garlic. Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (50 mg/kg) in male rats. Rats were fed with raw fresh garlic homogenate (250 mg/kg) six days a week by gavage for a period of 6 weeks. At the end of the 6th week blood samples and heart tissues were collected and used for determination of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and histological evaluation. Induction of diabetes increased MDA levels in blood and homogenates of heart. In diabetic rats treated with garlic, MDA levels decreased in blood and heart homogenates. Treatment of diabetic rats with garlic increased SOD, GPX and CAT in blood and heart homogenates. Histopathological finding of the myocardial tissue confirmed a protective role for garlic in diabetic rats. Thus, the present study reveals that garlic may effectively modulate antioxidants status in the blood and heart of streptozotocin induced-diabetic rats.

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The effects of lycopene on hepatic ischemia/reperfusion injury in rats

Bayramoğlu

Altuner

et al. 2014

Cytotechnology

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There is a very little information about the protective effect of lycopene (LYC) against hepatic ischemia–reperfusion injury. The present study was designed to examine the possible protective effect of the strong antioxidant and anti-inflammatory agent, LYC, on hepatic ischemia/reperfusion injury. For this purpose, rats were subjected to 45 min of hepatic ischemia followed by 60 min of reperfusion period. LYC at the doses of 2.5 and 5 mg/kg body weight (bw) were injected intraperitoneally, 60 min prior to ischemia. Upon sacrification, hepatic tissue samples were used for the measurement of catalase (CAT) activity and malondialdehyde (MDA) levels. Also, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were assayed in serum samples. As a result of the use of LYC at the doses of 2.5 and 5 mg/kg bw; while improvements of the ALT, AST, LDH and MDA values were partial and dose-dependent, the improvement of CAT activity was total and dose-independent (p < 0.05). Our findings suggest that LYC has a protective effect against ischemia/reperfusion injury on the liver.

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Pioglitazone Attenuates Ischemia/Reperfusion–Induced Liver Injury in Rats

Cited by 34 publications

References 31 publications

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

The effects of lycopene on hepatic ischemia/reperfusion injury in rats

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