Abstract:Aims
Heart failure (HF) often results from mechanical or neurohormonal stress and remains the mortality up to 45–50%, which is accompanied by cardiomyocytes loss, apoptosis, and fibrosis. Pinoresinol diglucoside (PDG), a compound obtained from with Forsythia suspensa, Epicommia ulmoides and Styrax sp., has a remarkable effect on anti-hypertension, anti-inflammation and anti-oxidative stress. However, whether PDG protects against pressure overload induced cardiomyocytes fibrosis, apoptosis and oxidative stress… Show more
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