Pimecrolimus and Tacrolimus for the Treatment of Intertriginous and Facial Psoriasis

High-concentration (20 μg g−1 ) tacalcitol ointment in the treatment of facial psoriasis: an 8-week open-label clinical trial

“…There are some previous reports in the literature of nonsteroidal treatment modalities for facial psoriasis. Among these modalities, calcineurin inhibitors have proven to be an effective drug in the topical treatment of facial psoriasis 14–17 . In addition, calcitriol, a vitamin D 3 analogue, has been reported to be effective for the treatment of psoriasis involving sensitive areas 16,18,19 …”

“…Among these modalities, calcineurin inhibitors have proven to be an effective drug in the topical treatment of facial psoriasis. [14][15][16][17] In addition, calcitriol, a vitamin D 3 analogue, has been reported to be effective for the treatment of psoriasis involving sensitive areas. 16,18,19 Tacalcitol has been developed with the purpose of maintaining the potent cell-regulating properties of calcitriol without the calcium-associated adverse effects, 20 and it is structurally different from calcitriol by the position of hydroxylation.…”

Treatment of intertriginous psoriasis: From the Medical Board of the National Psoriasis Foundation

“…Their efficacy has been documented in small open and blinded studies. [5][6][7][8][9][10][11][12][16][17][18] Although topical steroids may be slightly more effective, the lack of significant side effects positions these agents as first-line choices. These medications may produce a slightly higher incidence of local adverse events in the skin fold but these problems have been minor and transient.…”

New topical immunological treatments for psoriasis

“…Their major adverse effect is skin atrophy, which is particularly marked in intertriginous areas and on the face and medial aspect of the thighs in adolescents. An alternative to topical steroids for the treatment of psoriasis in these sites would therefore be very desirable and has justified numerous trials conducted with other anti‐inflammatory or immunomodulator derivatives 1 …”