Pilot study of topical calcitriol (1,25-dihydroxyvitamin D3) for treating psoriasis in children

Perez, A.

doi:10.1001/archderm.131.8.961

Cited by 8 publications

(8 citation statements)

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“…Both Smith et al (1988), in a study of 17 subjects in a 6-week trial, and Perez et al (1995) in a study of 4 children for a period of 8 weeks, reported favourable results with calcitriol, but this compound is associated with the risk of hypercalcinuria, hypercalcaemia and induction of bone resorption.…”

Section: Discussionmentioning

confidence: 99%

Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo‐controlled, double‐blind study*

Syed

Holt

Ahmad

et al. 1996

Tropical Med Int Health

181

124

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SummaryThe purpose of this double-blind, placebo-controlled study was to evaluate the clinical efficacy and tolerability of topical Aloe veru extract 0.5% in a hydrophilic cream to cure patients with psoriasis vulgaris. Sixty patients (36Mf24F) aged 18-50 years (mean 25.6) with slight to moderate chronic plaque-type psoriasis and PASI (Psoriasis Area and Severity Index) scores between 4.8 and 16.7 (mean 9.3) were enrolled and randomized to two parallel groups. The mean duration of the disease prior to enrolment was 8.5 years (range 1-21). Patients were provided with a precoded IOO g tube, placebo or active (with 0.5% Aloe veru extract), and they self-administered trial medication topically (without occlusion) at home 3 times daily for 5 consecutive days per week (maximum 4 weeks active treatment). Patients were examined on a weekly basis and those showing a progressive reduction of lesions, desquamation followed by decreased erythema, infiltration and lowered PASI score were considered healed. The study was scheduled for 16 weeks with 12 months of follow-up on a monthly basis. The treatment was well tolerated by all the patients, with no adverse drug-related symptoms and no dropouts. By the end of the study, the Aloe veru extract cream had cured 25/30 patients (83.3%) compared to the placebo cure rate of 2/30 (6.6%) (P

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Section: Discussionmentioning

confidence: 99%

Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo‐controlled, double‐blind study*

Syed

Holt

Ahmad

et al. 1996

Tropical Med Int Health

181

124

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“…Furthermore, a systematic review of all treatments for childhood plaque psoriasis recommends calcipotriene and calcitriol as effective and well-tolerated treatments (level of evidence A and B, respectively) 26. Indeed, although not officially approved for their use in juvenile psoriasis, their efficacy is documented and evidence-based 27–29…”

Section: Management Of Psoriasis In Adolescencementioning

confidence: 99%

Management of psoriasis in adolescence

Fotiadou¹,

Lazaridou²,

Ioannides³

2014

AHMT

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Psoriasis is a chronic inflammatory cutaneous disorder affecting 2%–4% of the world’s population. The prevalence of the disease in childhood and adolescence ranges between 0.5% and 2%. The management of psoriasis in adolescence is an intriguing and complicated task. Given the paucity of officially approved therapies, the very limited evidence-based data from randomized controlled trials, and the absence of standardized guidelines, physicians must rely on published experience from case reports both from the field of dermatology as well as from the application of these drugs for other pediatric conditions coming from the disciplines of rheumatology, gastroenterology, and oncology. Psoriatic adolescents deal with a potentially disfiguring and lifelong disease that could permanently impair their psychological development. It must be clarified to them that psoriasis does not have a permanent cure, and therefore the main goal of treatments is to establish disease control and prolonged periods between flares. The majority of adolescents suffer from mild psoriasis, and thus they are treated basically with topical treatment modalities. Phototherapy is reserved for adolescents with mild-to-moderate plaque disease and/or guttate psoriasis when routine visits to specialized centers do not create practical problems. Systemic agents and biologics are administered to patients with moderate-to-severe plaque psoriasis, pustular psoriasis, or erythrodermic psoriasis.

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“…[18][19][20][21][22][23][24][25][26][27] One case report 27 was excluded because of an unclear diagnosis.…”

Section: Vitamin D Analoguesmentioning

confidence: 99%

Efficacy and safety of treatments for childhood psoriasis: A systematic literature review

Jager

Jong

Kerkhof

et al. 2010

Journal of the American Academy of Dermatology

128

148

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Pilot study of topical calcitriol (1,25-dihydroxyvitamin D3) for treating psoriasis in children

Cited by 8 publications

References 0 publications

Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo‐controlled, double‐blind study*

Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo‐controlled, double‐blind study*

Management of psoriasis in adolescence

Efficacy and safety of treatments for childhood psoriasis: A systematic literature review

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