2006
DOI: 10.1007/s00280-005-0114-4 View full text |Buy / Rent full text
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Abstract: Weekly chemotherapy with paclitaxel and carboplatin was well- tolerated and gave a high-response rate in pts with refractory or relapsed small-cell lung cancer.

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“…Combination regimens like carboplatin/irinotecan or carboplatin/paclitaxel demonstrated overall response rates of 68% and 69% and a median overall survival of 6.5 and 7 months, respectively [11,12]. Although the survival in these trials is comparable to our trial an unfavourable toxicity has been reported with these combination regimens.…”
Section: Discussionmentioning
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“…Combination regimens like carboplatin/irinotecan or carboplatin/paclitaxel demonstrated overall response rates of 68% and 69% and a median overall survival of 6.5 and 7 months, respectively [11,12]. Although the survival in these trials is comparable to our trial an unfavourable toxicity has been reported with these combination regimens.…”
Section: Discussionmentioning
“…Although the survival in these trials is comparable to our trial an unfavourable toxicity has been reported with these combination regimens. The rates of grade III and IV neutropenia were 63% and 55%, grade III and IV thrombocytopenias occurred in 58% and 3% and grade III and IV anemias in 67% and 36% of patients [11,12].…”
Section: Discussionmentioning
“…These studies have highlighted 2 major prognostic factors associated with long-term survival (in multivariate analysis): PS and first-line chemotherapy response. Baseline PS before chemotherapy is the most important prognostic factor predicting prolonged survival [12][13][14][15][16][17][18][19][20][21][22] . The characteristics of our patients joined these results: their PS were at 0 and they had responded well to a first-line treatment.…”
Section: Discussionmentioning
“…It is prepared from seven herbs, Pinelliae tuber, Scutellariae radix, Zingiberis rhizoma, Ginseng radix, Glycyrrhizae radix, Zizyphi fructus, and Coptidis rhizoma. Hange-shashin-to has been shown to effectively prevent irinotecan-induced delayed diarrhea, both in animal experiments [27] and in a randomized study of patients with advanced non-small-cell lung cancer [28].…”
Section: Hange-shashin-tomentioning