Pigmented Purpuric Dermatosis Associated With Creatine Supplementation

Chorny, Joe A.; Cohen, J.

doi:10.1001/archderm.142.12.1662

Cited by 8 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, this is the only case of diet‐induced PPD reported in the literature, which – in contrast to the patient of Chorny and Cohen – could also be rapidly rechallenged by dietary factors. This clearly shows the clinical benefit achieved by mere withdrawal of the dietary trigger.…”

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Diet‐induced pigmented purpuric dermatosis

et al. 2013

View full text Add to dashboard Cite

Pigmented purpuric dermatoses (PPD) are chronic and relapsing disorders characterised by a localised or generalised purpuric rash. Even though the clinical presentation of PPD subtypes varies, they have a similar histopathology. The aetiology is largely unknown, but trigger factors, such as drugs, infections and systemic illnesses have been described. To our knowledge, this is the only case showing widespread PPD lesions not only induced but also rapidly provoked by dietary factors, namely Coca Cola and apple-cherry fruit spritzer.

show abstract

Section: Discussionmentioning

confidence: 73%

“…Avoiding Coca Cola and the apple‐cherry fruit spritzer mentioned prevented the formation of new skin lesions and even led to a notable pallor of existing pigment deposits, as was reported in another case of dietary PPD …”

Section: Case Reportmentioning

confidence: 64%

Diet‐induced pigmented purpuric dermatosis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…A National Institute of Health‐sponsored phase‐III trial of Cr in the initial stage of Parkinson's disease is currently under way (http://www.parkinsontrial.ninds.nih.gov/). Anecdotal reports have sometimes suggested some possible adverse effects of Cr administration, including ischemic stroke, atrial fibrillation, kidney damage, cholestatic liver injury, rhabdomyolysis, and pigmented purpuric dermatosis . However, a cause‐and‐effect relationship has not been convincingly demonstrated …”

Section: Clinical Use Of Creatine or Its Derivativesmentioning

confidence: 99%

Therapeutic Use of Creatine in Brain or Heart Ischemia: Available Data and Future Perspectives

Perasso

Spallarossa

Ruggeri

et al. 2011

Medicinal Research Reviews

View full text Add to dashboard Cite

Creatine (Cr) is essential in safeguarding ATP levels and in moving ATP from its production site (mitochondria) to the cytoplasmic regions where it is used. Moreover, it has effects unrelated to energy metabolism, such as free radical scavenging, antiapoptotic action, and protection against excitotoxicity. Recent research has studied Cr-derived compounds (Cr benzyl ester and phos-pho-Cr-magnesium complex) that reproduce the neuroprotective effects of Cr while better crossing the neuronal plasma membrane and, hopefully, the blood-brain barrier (BBB). Intracellular levels of Cr can be increased by incubation with Cr or some of its derivatives, and this increase is protective against anoxic or ischemic damage. A large amount of experimental evidence shows that pretreatment with Cr is capable of reducing the damage induced by ischemia or anoxia in both heart and brain, and that such treatment may also be useful even after stroke or myocardial infarction (MI) has already occurred. Cr has been safely administered to patients affected by several neurological diseases, yet it has never been tested in human brain ischemia, the condition where its rationale is strongest. Phosphocreatine (PCr) has been administered after human MI, where it proved to be safe and probably helpful. Cr should be tested in the prophylactic protection against human brain ischemia and either Cr or PCr should be further tested in MI. Moreover, Cr- or PCr-derived drugs should be developed in order to overcome these molecules' limitations in crossing the BBB and the cell plasma membrane.

show abstract

“…As the child was in good health and no signs of a venous or hematologic disease were present, the regular consumption of an energy drink containing caffeine, taurine, glucuronolactone and B‐complex vitamins was suspected to be the trigger for the purpuric disease. While most cases of purpuric pigmented dermatoses remain idiopathic, certain medications or even dietary supplements such as creatine 14 can cause the vascular leakage and extravasation of erythrocytes. Whether the causative ingredient was taurin, glucoronolactone or B‐vitamins remains unclear, as an oral challenge of the ingredients of the energy drink was not performed because of the wish of the parents.…”

Section: Discussionmentioning

confidence: 99%

Lichen aureus with clonal T cells in a child possibly induced by regular consumption of an energy drink

2008

View full text Add to dashboard Cite

Lichen aureus is a rare disease of unknown origin that is classified under the group of pigmented purpuric dermatoses. Its most important differential diagnosis is both clinically and histologically mycosis fungoides, into which the disease can proceed in very rare cases. We describe an unusual multilocular lichen aureus possibly induced by the almost daily consumption of an energy drink. An 11-year-old boy presented with a history of asymptomatic ochre patches on his extremities and abdomen occurring after regular consumption of an energy drink. Histologic examination showed a band-like lymphocytic infiltrate, containing hemosiderin deposits and extravasal erythrocytes adjacent to dermal blood vessels, in the iron-stain detection of hemosiderin. Because of these findings, lichen aureus was diagnosed. After a 2-month abstention from the energy drink, no new lesions appeared and the present lesions grew pale and finally disappeared. The case shows a rare multilocular lichen aureus, which disappeared after the consumption of an energy drink was stopped. The ingredients of the energy drink are an example of a possible trigger of the disease.

show abstract

Pigmented Purpuric Dermatosis Associated With Creatine Supplementation

Cited by 8 publications

References 1 publication

Diet‐induced pigmented purpuric dermatosis

Diet‐induced pigmented purpuric dermatosis

Therapeutic Use of Creatine in Brain or Heart Ischemia: Available Data and Future Perspectives

Lichen aureus with clonal T cells in a child possibly induced by regular consumption of an energy drink

Contact Info

Product

Resources

About