Pigmented mammary Paget's disease mimicking melanoma: report of three cases

Pigmented macule on the nipple

“…As in this case, pigmented MPD should also be considered when the pigmented macule is located on the nipple. Because MM does not show specific features on the nipple, it is difficult to distinguish pigmented MPD from MM by dermoscopy . To our knowledge, six cases of pigmented MPD have been reported to date with dermoscopic findings.…”

“…To our knowledge, six cases of pigmented MPD have been reported to date with dermoscopic findings. Five of these cases presented with irregular pigmentation, and four cases presented with irregular dots/globules and blue–white structures, including blue–white veil and regression structures . These six cases showed dermoscopic features similar to our case, and were indistinguishable from MM under dermoscopy.…”

“…Because MM does not show specific features on the nipple, it is difficult to distinguish pigmented MPD from MM by dermoscopy. 3 To our knowledge, six cases of pigmented MPD have been reported to date with dermoscopic findings. Five of these cases presented with irregular pigmentation, and four cases presented with irregular dots/globules and blue-white structures, including blue-white veil and regression structures.…”

Pigmented mammary Paget's disease presenting with dermoscopic features of multiple dots

“…The gross appearance and dermoscopic changes of PMPD resemble those of melanoma arising on extra‐mammary skin and no specific dermoscopic features of PMPD are known. Although there have been a few cases of PMPD with reticular pigmentation, it is noteworthy that the reticular pigmentation of the patient in this study was composed of numerous double‐lined dots and fine lines. We have seen no previous report of this type of pigmentation.…”

Five patients with melanosis of the nipple and areola clinically mimicking melanoma

“…9 Approximately 40 cases of pigmented mammary Paget's disease have been reported in the medical literature. 10 The underlying mechanism of the pigmentation is not clear, but it has been proposed that Paget cells may release melanocytic chemoattractants or basic fibroblast growth factors that stimulate the proliferation of melanocytes within the tumour nests. 11 Melanosis would appear to be the rarest of these three entities.…”