Pigmentary Glaucoma

Yang, Jin; Sakiyalak, Darin; Krupin, Theodore

doi:10.1097/00061198-200110001-00012

Cited by 30 publications

(24 citation statements)

References 11 publications

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“…In RPB, the iris functions as a flap valve, allowing aqueous humor to pass from the posterior chamber to the anterior chamber but not in the opposite direction [2]. The aqueous humor trapped within the anterior chamber causes posterior bowing of the peripheral iris.…”

Section: Introductionmentioning

confidence: 99%

Reverse pupillary block after implantation of a scleral-sutured posterior chamber intraocular lens: a retrospective, open study

2017

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BackgroundTo report the clinical features of patients with reverse pupillary block (RPB) after scleral-sutured posterior chamber intraocular lens (PC IOL) implantation and biometric changes after laser peripheral iridotomy (LPI).MethodsEight patients attending our hospital’s ophthalmology outpatient clinic, who developed RPB after implantation of a scleral-sutured PC IOL due to subluxation of the crystalline lens or IOL, were investigated in this retrospective, observational study.ResultsPreoperative evaluations showed angle pigmentation in all cases and iridodonesis in 2 cases. Two subjects had used an α1A-adrenoceptor antagonist for benign prostatic hyperplasia. Pars plana or anterior partial vitrectomy was performed in all cases. All eyes showed an extremely deep anterior chamber, a concave iris configuration, and contact between the IOL optic and the iris at the pupillary margin. Pupil capture was detected in 2 cases. The mean (± SD) anterior chamber angle (ACA) was 89.91 ± 10.06°, and the anterior chamber depth (ACD) was 4.42 ± 0.16 mm before LPI. After LPI, the iris immediately became flat with a decreased ACA (51.70 ± 2.59°; P = 0.018) and ACD (4.14 ± 0.15 mm; P = 0.012). After LPI, the intraocular pressure decreased from 19.75 ± 3.77 mmHg to 15.63 ± 4.30 mmHg (P = 0.011), and the spherical equivalent decreased from -0.643 ± 0.385 D to − 0.875 ± 0.505 D (P = 0.016).ConclusionConcomitant vitrectomy, angle pigmentation, and iridodonesis may be risk factors for RPB after scleral-sutured PC IOL implantation. LPI is effective for relieving the RPB.

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Section: Introductionmentioning

confidence: 99%

Reverse pupillary block after implantation of a scleral-sutured posterior chamber intraocular lens: a retrospective, open study

2017

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“…It is estimated that pigmentary glaucoma affects 0.5% to 5% of people with glaucoma in the Western world (Ritch 1997; Yang 2001). Pigmentary glaucoma was found in 0.6% of a cohort of 176 people with glaucoma (95% confidence interval (CI) 0.01% to 3%) in the Congo (Kaimbo Wa Kaimbo 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Most people with pigmentary glaucoma are men, and the disease tends to develop at an earlier age among men than among women (Migliazzo 1986; Scheie 1981; Sugar 1966; Yang 2001). Pigmentary glaucoma is diagnosed most commonly in the third and fourth decades of life, although the average age of onset is uncertain (Speakman 1981).…”

Section: Introductionmentioning

confidence: 99%

Peripheral iridotomy for pigmentary glaucoma

Michelessi

Lindsley

2016

Cochrane Database of Systematic Reviews

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BackgroundGlaucoma is a chronic optic neuropathy characterized by retinal ganglion cell death resulting in damage to the optic nerve head and the retinal nerve fiber layer. Pigment dispersion syndrome is characterized by a structural disturbance in the iris pigment epithelium (the densely pigmented posterior surface of the iris) that leads to dispersion of the pigment and its deposition on various structures within the eye. Pigmentary glaucoma is a specific form of open-angle glaucoma found in patients with pigment dispersion syndrome.Topcial medical therapy is usually the first-line treatment; however, peripheral laser iridotomy has been proposed as an alternate treatment. Peripheral laser iridotomy involves creating an opening in the iris tissue to allow drainage of fluid from the posterior chamber to the anterior chamber and vice versa. Equalizing the pressure within the eye may help to alleviate the friction that leads to pigment dispersion and prevent visual field deterioration. However, the effectiveness of peripheral laser iridotomy in reducing the development or progression of pigmentary glaucoma is unknown. ObjectivesThe objective of this review was to assess the effects of peripheral laser iridotomy compared with other interventions, including medication, trabeculoplasty, and trabeculectomy, or no treatment, for pigment dispersion syndrome and pigmentary glaucoma. Search methodsWe searched a number of electronic databases including CENTRAL, MEDLINE and EMBASE and clinical trials websites such as (mRCT) and ClinicalTrials.gov. We last searched the electronic databases on 2 November 2015. Selection criteriaWe included randomized controlled trials (RCTs) that had compared peripheral laser iridotomy versus no treatment or other treatments for pigment dispersion syndrome and pigmentary glaucoma. Data collection and analysisWe used standard methodological procedures for systematic reviews. Two review authors independently screened articles for eligibility, extracted data, and assessed included trials for risk of bias. We did not perform a meta-analysis because of variability in reporting and follow-up intervals for primary and secondary outcomes of interest.

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“…PDS patients accumulate pigment within the trabecular meshwork, and a subset (approximately 35% by 35 years following PDS diagnosis) develop pigmentary glaucoma (PG) [4]. This condition accounts for 1–1.5% of human glaucoma cases seen in the Western world [5]. Although the PDS causative mutation/s has yet to be identified, the phenotype has been linked to the telomere region (7q35-q36) of human chromosome 7 [6].…”

Section: Introductionmentioning

confidence: 99%

Exclusion of eleven candidate genes for ocular melanosis in cairn terriers

Winkler

Bartoe

Quinones

et al. 2013

J Negat Results BioMed

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BackgroundOcular melanosis of Cairn terrier dogs is an inherited defect characterized by progressive pigmentation of both eyes which can result in glaucoma and blindness. Pedigree analysis suggests the trait has an autosomal dominant mode of inheritance. We selected 11 potential candidate genes and used an exclusion analysis approach to investigate the likelihood that one of the candidate gene loci contained the Cairn terrier-ocular melanosis locus.ResultsTwo polymorphic loci were identified within or close to each candidate gene. Genotyping of at least 10 ocular melanosis Cairn terriers for each marker showed that there was no single shared allele for either of the two polymorphic markers identified in ASIP, COMT, GPNMB, GSK3B, LYST, MC1R, MITF, SILV, TYR, TYRP1,and TYRP2. This is strong evidence to exclude each locus as the site of the ocular melanosis mutation (probability of a false exclusion calculated for each gene ranged from 1.59 × 10-4 to 1 × 10-9).ConclusionsNone of the 11 potential candidate genes selected are likely to be the gene locus for ocular melanosis in Cairn terriers.

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Pigmentary Glaucoma

Cited by 30 publications

References 11 publications

Reverse pupillary block after implantation of a scleral-sutured posterior chamber intraocular lens: a retrospective, open study

Reverse pupillary block after implantation of a scleral-sutured posterior chamber intraocular lens: a retrospective, open study

Peripheral iridotomy for pigmentary glaucoma

Exclusion of eleven candidate genes for ocular melanosis in cairn terriers

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