Piecing together the puzzle of acetaldehyde as a neuroactive agent

Correa, Mercè; Salamone, John D.; Segovia, Kristen N.; Pardo, Marta; Longoni, R; Spina, Liliana; Peana, Alessandra Tiziana; Vinci, Stefania; Acquas, Elio

doi:10.1016/j.neubiorev.2011.07.009

Cited by 109 publications

(115 citation statements)

References 317 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…Many laboratories have tested the role of the ethanol metabolite acetaldehyde, by impairing its formation (see Correa et al, 2011 for review) or using acetaldehyde sequestering agents such as D-penicilamine (Enrico et al, 2009;Martí-Prats et al, 2010;Pautassi et al, 2010). All of these in vivo studies have shown that the behavioral, neurochemical, and electrophysiological properties of ethanol are impaired when acetaldehyde, and conse- quently salsolinol, cannot be formed (Enrico et al, 2009;Martí-Prats et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors

Xie

Hipólito²,

Zuo³

et al. 2011

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Previous studies in vivo have shown that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse. Although opioid receptors, especially the -opioid receptors (MORs), may be involved, the cellular mechanisms mediating the effects of salsolinol have not been fully explored. In the current study, we used whole-cell patch-clamp recordings to examine the effects of salsolinol on dopamine neurons of the ventral tegmental area (VTA) in acute brain slices from Sprague-Dawley rats. Salsolinol (0.01-1 M) dose-dependently and reversibly increased the ongoing firing of dopamine neurons; this effect was blocked by naltrexone, an antagonist of MORs, and gabazine, an antagonist of GABA A receptors. We further showed that salsolinol reduced the frequency without altering the amplitude of spontaneous GABA A receptor-mediated inhibitory postsynaptic currents in dopamine neurons. The salsolinol-induced reduction was blocked by both naltrexone and [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin, an agonist of MORs. Thus, salsolinol excites VTA-dopamine neurons indirectly by activating MORs, which inhibit GABA neurons in the VTA. This form of disinhibition seems to be a novel mechanism underlying the effects of salsolinol.

show abstract

Section: Discussionmentioning

confidence: 99%

Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors

Xie

Hipólito²,

Zuo³

et al. 2011

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

Section: Ethanol Acetaldehyde and Salsolinolmentioning

confidence: 99%

“…Significant evidence implicates the first metabolite of ethanol, acetaldehyde, in the mechanisms underlying the psychopharmacological effects of ethanol (Correa et al, 2012). In fact, it has been demonstrated that acetaldehyde has rewarding properties per se (Correa et al, 2012). The relevance of the role of acetaldehyde in the VTA is further supported by the local presence of the enzymatic machinery necessary to metabolize ethanol (Moreno et al, 1995;Sanchez-Catalan et al, 2008).…”

Section: Ethanol Acetaldehyde and Salsolinolmentioning

confidence: 99%

The antero-posterior heterogeneity of the ventral tegmental area

et al. 2014

View full text Add to dashboard Cite

“…Acetaldehyde, the first metabolite of alcohol, has been suggested to be involved in many behavioral effects after ethanol administration (Correa et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults

Chen

et al. 2012

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with alcohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant differences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It may also affect some blood biochemical indicators, but the specific mechanisms need further research.

show abstract

Piecing together the puzzle of acetaldehyde as a neuroactive agent

Cited by 109 publications

References 317 publications

Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors

Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors

The antero-posterior heterogeneity of the ventral tegmental area

Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults

Contact Info

Product

Resources

About