Abstract:PICK1 binds to protein kinase C␣ (PKC␣) through the carboxylate-binding loop in its PDZ (PSD95/Disc-large/ ZO-1) domain and the C terminus of PKC␣. We have previously shown that PICK1 modulates the catalytic activity of PKC selectively toward the antiproliferative gene TIS21. To investigate whether PICK1 plays a role in targeting activated PKC␣ to a particular intracellular compartment in addition to regulating PKC activity, we examine the localization of PICK1 and PKC␣ in response to various stimuli. Double s… Show more
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