volume 25, issue 1, P111-117 2011
DOI: 10.3233/jad-2011-101917
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Hong-Lei Li, Sheng-Sheng Shi, Qi-Hao Guo, Wang Ni, Yi Dong, Ying Liu, Yi-Min Sun, Bei-Wang, Shen-Ji Lu, Zhen Hong, Zhi-Ying Wu

Abstract: Alzheimer's disease (AD) is the most common form of senile dementia, and the overall prevalence increases exponentially with age. It is well known that genetic variants may play an important role in the pathogenesis of this disorder. Recently, two independent large-scale genome-wide association studies (GWAS) identified 3 novel single nucleotide polymorphisms (SNPs) (rs11136000 within CLU, rs3851179 within PICALM and rs6656401 within CR1) that are associated with late-onset AD (LOAD), and these results have be…

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