PIAS3 expression in human gastric carcinoma and its adjacent non-tumor tissues

Liu, Liangming; Yan, Ming-guo; Yang, Dong; Sun, Weiwei; Zhang, Jixiang

doi:10.1016/j.clinre.2010.12.002

Cited by 13 publications

(14 citation statements)

References 25 publications

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“…In the current study we clearly observed that TRIM8 positively regulates TNF mediated NF-κB activation suggesting that it may activate postive feedback loop that may be crucial for tumorigenesis. This hypothesis is further supported by the loss of expression of PIAS3, the target of TRIM8, in many tumors including human gastric carcinoma [39] and glioblastoma multiforme tumors [40]. The observation of TRIM8 mediated increase in cell motlity and clonogenic ability further supports that TRIM8 may act as tumor promoter in specific conditions.…”

Section: Discussionmentioning

confidence: 69%

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

Tomar¹,

Sripada²,

Prajapati³

et al. 2012

PLoS ONE

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TNF induced nuclear factor kappa B (NF-κB) is one of the central signaling pathways that plays a critical role in carcinogenesis and inflammatory diseases. Post-translational modification through ubiquitin plays important role in the regulation of this pathway. In the current study, we investigated the role of TRIM8, member of RING family ubiquitin ligase in regulation of NF-κB pathway. We observed that TRIM8 positively regulates TNF induced NF-κB pathway. Different domains of TRIM8 showed discrete functions at the different steps in regulation of TNF induced NF-κB pathway. Ubiquitin ligase activity of TRIM8 is essential for regulation of NF-κB activation in both cytoplasm as well as nucleus. TRIM8 negates PIAS3 mediated negative repression of NF-κB at p65 by inducing translocation of PIAS3 from nucleus to cytoplasm as well as its turnover. TNF induces translocation of TRIM8 from nucleus to cytoplasm, which positively regulates NF-κB. The cytoplasmic translocation of TRIM8 is essential for TNF induced NF-κB but not for p65 mediated NF-κB regulation. TRIM8 also enhanced the clonogenic and migration ability of cells by modulating NF-κB. The further study will help to understand the role of TRIM8 in inflammation and cancer.

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Section: Discussionmentioning

confidence: 69%

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

Tomar¹,

Sripada²,

Prajapati³

et al. 2012

PLoS ONE

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“…Colon Diagnosis, prognosis [61] Gastric Diagnosis, prognosis, therapeutic predictivity [62,63] Prostate Diagnosis [64] Breast Prognosis [44] PIAS3 Lung, breast, prostate, colorectal, brain Diagnosis [65,66] Ovarian, endometrial Diagnosis [67] Squamous cell carcinoma of the lung Diagnosis [68] Gastric Diagnosis, prognosis [69] PIAS4 Gastric Therapeutic predictivity [63] Breast Prognosis [70] MDS Diagnosis, progression [71] RanBP2 Multiple myeloma Diagnosis [72] Small cell lung cancer Diagnosis [73] Inflammatory myofibroblastic tumor Diagnosis, prognosis, therapeutic predictivity, risk assessment [74,75] Acute myelomonocytic leukemia Diagnosis, risk assessment [76,77] 8p11 myeloproliferative syndrome Diagnosis, risk assessment [78] Pc2 Hepatocellular carcinoma Prognosis [79] TRIM19 AML Diagnosis [80] TRIM27 Endometrial Prognosis [81] Colon Prognosis [82] Ovarian Prognosis, therapeutic predictivity [83] SENP1 Prostate Diagnosis, prognosis, therapeutic predictivity [84][85][86] Pancreatic ductal adenocarcinoma Diagnosis, prognosis [87] SENP2 Bladder Diagnosis [88] Hepatocellular carcinoma Diagnosis [89] SENP3 Colon, rectum, ovarian, lung, oral squamous cell carcinoma Diagnosis [90,91] …”

Section: Pias1mentioning

confidence: 99%

“…For example, increased PIAS3 was observed by IHC screening in a variety of human cancers, including lung, breast, prostate, brain and colorectal cancers, where it may be used as a useful molecular marker [65,66]. On the contrary, PIAS3 downregulation can be used as a valuable tool in ovarian and endometrial cancers [67], in squamous cell carcinoma of the lung [68], and in gastric carcinoma where the decreased expression levels of PIAS3 protein and mRNA in cancerous tissues were closely related to large tumor size and poor differentiation [69].…”

Section: • • E3 Enzymesmentioning

confidence: 99%

SUMO pathway components as possible cancer biomarkers

Mattoscio

Chiocca

2015

Future Oncol.

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SUMOylation is a key post-translational modification that regulates crucial cellular functions and pathological processes. Recently, Small Ubiquitin-related MOdifier (SUMO) modification has emerged as a fundamental route that may drive different steps of human tumorigenesis. Indeed, alteration in expression or activity of one of the different SUMO pathway components may completely subvert cellular properties through fine-tuning modulation of protein(s) involved in carcinogenic pathways, leading to altered cell proliferation, apoptosis resistance and metastatic potential. Here we describe some of the most interesting findings pointing to a clear link between SUMO pathway and human malignancies. Importantly, a putative role for SUMO enzymes to predict cancer behavior can be speculated, and thus the possible application of alterations in SUMO pathway components as tumor biomarkers is discussed.

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“…3 and 4). PIAS3 can affect the growth of cancer cells in some malignancy (Ogata et al 2006;Liu et al 2011). Here, we found that the level of PIAS3 was lower in CRC patients were at advanced stage.…”

Section: The Protein Levels Of Hv1 Mxra5 Pias3 and Dek In Crc Patientsmentioning

confidence: 68%

“…Glioblastoma and squamous cell lung cancer lack PIAS3 expression (Dabir et al 2011). PIAS3 can affect the growth of cancer cells by inhibiting the JAK/STAT and PI3-K/Akt signaling pathways or regulating its SUMO (small-ubiquitin like modifiers) ligase activity in some malignancy (Liu et al 2011). DEK protein is related to chromatin reconstruction and gene transcription, and plays an important role in cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Association of Sedentary Behavior with the Expression Levels of Biomarkers in Colorectal Cancer: Clinical Analysis of 228 Patients

Takata

Lü

et al. 2014

Tohoku J. Exp. Med.

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There is an association between sedentary behavior and the risk of colorectal cancer (CRC), but the underlying mechanism is unclear. CRC is characterized by the changes in the expression levels of biomarkers, including voltage-gated proton channel Hv1, matrix-remodeling associated 5 (MXRA5), DEK (inducing positive supercoils into circular DNA) and protein inhibitor of activated signal transducer and activators of transcription 3 (PIAS3). Thus, sedentary behavior may affect the expression levels of these biomarkers in the colorectal tissue. Here, we recruited 228 CRC patients (128 males, 57.8 ± 7.8 years; 100 females, 57.7 ± 7.5 years) and 80 healthy subjects (48 males, 57.5 ± 6.8 years; 32 females, 56.9 ± 6.5 years) from March 7th, 2010 to May 6th, 2012. All the subjects were unrelated Han Chinese with the similar cultural and economic background. All the subjects were interviewed concerning sedentary time (sitting time categories: less than 1, 1-3, 4-6, and more than 6 h/day). The daily sedentary time of most CRC patients was more than 4 h/day, while the sedentary time of most healthy subjects was less than 3 h/ day. The expression levels of Hv1, MXRA5 and DEK mRNAs and proteins were higher in CRC tissues and the levels of PIAS3 mRNA and protein were lower when the daily sedentary time was longer in CRC patients (p < 0.05). The daily sedentary time was correlated with the protein levels of CRC biomarkers. Furthermore, the sedentary time was positively related with body mass index but not daily calorie intake.

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PIAS3 expression in human gastric carcinoma and its adjacent non-tumor tissues

Cited by 13 publications

References 25 publications

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

SUMO pathway components as possible cancer biomarkers

Association of Sedentary Behavior with the Expression Levels of Biomarkers in Colorectal Cancer: Clinical Analysis of 228 Patients

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