Phytotoxic compounds produced by Fusarium equiseti. Part II. The chemistry of diacetoxyscirpenol

Dawkins, A. W.

doi:10.1039/j39660000116

Cited by 17 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several protein synthesis inhibitors are already known and have been extensively studied. These especially include homoharringtonine [32], anguidine [33], bruceantin [34] and sparsomycin [35]. Novel marine natural products mycalamide.…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity and mechanism of action of the marine compound girodazole

et al. 1991

View full text Add to dashboard Cite

Girodazole, a new marine compound has been isolated from the sponge Pseudaxinyssa cantharella. Girodazole is active in vivo on several murine grafted tumors including leukemias (P388, L1210, i.p./i.p.) and solid tumors (MA 16/C mammary adenocarcinoma, M5076 histiocytosarcoma, s.c./i.v.). In addition, girodazole has identical cytotoxic properties in vitro on P388 and P388/DOX cells and retains antitumor activity in vivo on P388/DOX. Girodazole has a unique chemical structure different from those of known anticancer agents and of new compounds undergoing clinical trials. Biochemical studies indicate that girodazole inhibits protein synthesis during the elongation/termination steps. Toxicological studies have been done in mice and in dogs and did not reveal any major toxic effect which could preclude administration in patients. Girodazole is now undergoing phase I clinical studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Antitumor activity and mechanism of action of the marine compound girodazole

et al. 1991

View full text Add to dashboard Cite

show abstract

“…Recently, several reports have appeared dealing with the nature of toxic substances produced by members of the genus Fusarium (Gilgan, Smalley and Strong,(1966) ;Dawkins,(1966);Yates et al,(1968)). All the toxic substances isolated by the above authors, however, are not the same.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Fusarenon on Multiplication of Tetrahymena Pyriformis

Nakano

1968

JJMSB

View full text Add to dashboard Cite

“…In spite of numerous reports of compounds elaborated by Fz~sarium species (for example, the antibiotic pigment bostrycoidin (2), the wilt toxin lycomarasmine (13), and the phytotoxin diacetoxyscirpenol (9)), there has been little study of the sterols produced by the fusaria. T h e present paper reports the results of a n investigation undertaken in these laboratories to icleiltify the sterols present in the rnycelia of Fz~sariz~m oxyspor~lm Schl.…”

Section: Introductionmentioning

confidence: 98%

Sterol and Fatty Acid Components of Mycelium of Fusarium Oxysporum

Starratt¹,

Madhosingh²

1967

Can. J. Microbiol.

View full text Add to dashboard Cite

A chloroform extract of the ~nycelium of Fzisarium oxysporzim Schl. em. Sny. et Hans. was analyzed for sterols; three major components were identified as ergosterol, ergosterol peroxide, and cerevisterol. The ratio of ergosterol to ergosterol peroxide formed was variable. Palmitic, stearic, oleic, and linoleic acids were identified by gas-liquid chromatography as the principal fatty acids of this organism.Fusaric acid, a phytotoxin previously obtained by other investigators from a number of forms of F. oxysporzi7it, was isolated fro111 the culture medium.

show abstract

Phytotoxic compounds produced by Fusarium equiseti. Part II. The chemistry of diacetoxyscirpenol

Cited by 17 publications

References 0 publications

Antitumor activity and mechanism of action of the marine compound girodazole

Antitumor activity and mechanism of action of the marine compound girodazole

Inhibitory Effects of Fusarenon on Multiplication of Tetrahymena Pyriformis

Sterol and Fatty Acid Components of Mycelium of Fusarium Oxysporum

Contact Info

Product

Resources

About