Phytophotodermatitis from celery among grocery store workers

Seligman, P. J.

doi:10.1001/archderm.123.11.1478

Cited by 30 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consumption of furanocoumarin-containing vegetables is not without risk since furanocoumarins can cause photosensitization, particularly in individuals who handle fresh produce such as celery [41]. Individuals treated for psoriasis and other skin conditions with pharmacological doses of furanocoumarins (specifically 8-methoxypsoralen) combined with ultraviolet A light (PUVA therapy) may be at increased risk of skin cancers due to the ability of furanocoumarin molecules to form complexes with DNA upon irradiation with ultraviolet light [49].…”

Section: Discussionmentioning

confidence: 99%

Effects of Furanocoumarins from Apiaceous Vegetables on the Catalytic Activity of Recombinant Human Cytochrome P-450 1A2

et al. 2011

View full text Add to dashboard Cite

Inhibition of cytochrome P-450 1A2 (CYP1A2)-mediated activation of procarcinogens may be an important chemopreventive mechanism. Consumption of apiaceous vegetables (rich in furanocoumarins) inhibits CYP1A2 in humans. Because many furanocoumarins are potent inhibitors of several CYP, we characterized the effects of three furanocoumarins from apiaceous vegetables on human CYP1A2 (hCYP1A2). We assessed hCYP1A2 methoxyresorufin O-demethylase (MROD) activity using microsomes from Saccharomyces cerevisiae expressing hCYP1A2. Isopimpinellin exhibited mechanism-based inactivation (MBI) of hCYP1A2 (Ki = 1.2 μM, kinact = 0.34 min−1, and partition ratio = 8). Imperatorin and trioxsalen were characterized as mixed inhibitors with Ki values of 0.007 and 0.10 μM, respectively. These results indicate that even if present at low levels in apiaceous vegetables, imperatorin, trioxsalen and isopimpinellin may contribute significantly to CYP1A2 inhibition and potentially decreased procarcinogen activation. Moreover, the in vivo effect of isopimpinellin on CYP1A2 may be longer lasting compared to reversible inhibitors.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Furanocoumarins from Apiaceous Vegetables on the Catalytic Activity of Recombinant Human Cytochrome P-450 1A2

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Phytophotodermatitis (a skin disorder caused by psoralens) has been reported m field workers after contact with celery (Austad and Kalvi, 1983;Birmingham et al, 1961;Finkelstein et al, 1994). Other studies (Berkley et al, 1986;Seligman et al, 1987) have found that phytophotodermatitis occurs in grocery workers. Psoralens also exist in other plants, such as parsnips, parsley, figs, and citrus (Pathak et al, 1961).…”

mentioning

confidence: 99%

Increasing Celery Resistance to Pathogens during Storage and Reducing High-risk Psoralen Concentration by Treatment with GA3

Afek¹,

Aharoni²,

Carmeli³

1995

jashs

View full text Add to dashboard Cite

Since psoralens have a very weak antifungal activity in vitro, we propose that (+)marmesin, the precursor of psoralens in celery (Apium graveolens L.) is associated with celery resistance to pathogens. (+)Marmesin has at least 100 times greater antifungal activity in vitro than psoralens. After 1 month of storage at 2C, the concentration of total psoralens increased from 8 to 67 µg·g -1 fresh weight, (+)marmesin decreased from 27 to 4 µg·g -1 fresh weight, and the incidence of decay increased from 0% to 34%. However, when celery was treated with GA 3 before 1 month of storage at 2C, decay increased to only 7%, the concentration of psoralens increased to 31 µg·g -1 fresh weight and the concentration of (+)marmesin decreased to 13 µg·g -1 fresh weight It seems that GA 3 retarded celery decay during storage by slowing down the conversion of (+)marmesin to psoralens, thereby increasing the resistance to pathogens during storage.

show abstract

“…Users of sunlamps are cautioned by the FDA (25) not to tan if taking medications that increase photosensitivity. Handling certain fruits and vegetables is likewise known to cause sometimes severe photodermatitis (26)(27)(28)(29) and The most significant hazard for both photosensitive and normal individuals associated with UV nail lamps is the potential for incorrect lamp, or bulb, substitution. The fluorescent UV nail lamps we evaluated had standard lamp bases.…”

Section: Discussionmentioning

confidence: 99%

Photobiological Safety Evaluation of UV Nail Lamps

Dowdy

Sayre

2013

Photochem & Photobiology

View full text Add to dashboard Cite

We evaluated six UV nail lamps representative of major US manufacturers to evaluate radiant hazards as defined in ANSI/IESNA RP-27 Recommended Practice for Photobiological Safety. Lamps were evaluated at three positions, 1 cm above the inner surface approximating exposure to the hand and the 20 cm RP-27 non-general light source distance, oriented normal and 45° to the opening. Hazard to skin at intended use distance classified these devices into Risk Group 1 or 2 (Low to Moderate) with S(λ) weighted Actinic UV ranging 1.2-1.7 μW cm(-2) and 29.8-276.25 min permissible daily exposure. At 20 cm on center and 45° UV risk to skin and eyes were all within Exempt classification. Actinic UV ranged 0.001-0.078 μW cm(-2) and unweighted near UV (320-400 nm) ranged 0.001-0.483 mW cm(-2). Likewise the retinal photochemical blue light hazard and retinal thermal and cornea/lens IR were also Exempt. One device had aphakic eye hazard slightly rising into Risk Group 1 (Low). There were no other photobiological risks to normal individuals. Total exposure following programmed times and steps accumulate to only a small fraction of RP-27 permissible daily occupational exposure. These risks are further mitigated in realistic nonoccupational use scenarios as it is unlikely to be a daily occurrence.

show abstract

Phytophotodermatitis from celery among grocery store workers

Cited by 30 publications

References 0 publications

Effects of Furanocoumarins from Apiaceous Vegetables on the Catalytic Activity of Recombinant Human Cytochrome P-450 1A2

Effects of Furanocoumarins from Apiaceous Vegetables on the Catalytic Activity of Recombinant Human Cytochrome P-450 1A2

Increasing Celery Resistance to Pathogens during Storage and Reducing High-risk Psoralen Concentration by Treatment with GA3

Photobiological Safety Evaluation of UV Nail Lamps

Contact Info

Product

Resources

About