Phytoestrogens from the roots of Polygonum cuspidatum (polygonaceae): structure-Requirement of hydroxyanthraquinones for estrogenic activity

Anti-estrogenic Activity of Mansorins and Mansonones from the Heartwood of Mansonia gagei DRUMM.

“…Among the known phytoestrogens, isoflavonoids, lignans and coumestans are the most well studied classes. Furthermore, other classes were also recently reported to possess estrogenic activities viz., anthraquinones, 3) retrodihydrochalcones, 4) and prenylated flavonoids. 5) In our current search for new phytoestrogens effective in the prevention and treatment of estrogen-mediated diseases, several medicinal plants known in Thailand folk medicine were investigated.…”

Phytoestrogens as Nutritional Modulators in Colon Cancer Prevention

“…These compounds are structurally similar and have a functional action as estrogen-agonists in mammals. Four classes of phytoestrogens can be distinguished, on the basis of their different molecular structure and different biological activities, namely isoflavones, lignans, coumestans and lactones (20)(21).…”

Alteration of Abiotic Stress Responsive Genes in Polygonum minus Roots by Jasmonic Acid Elicitation

“…Other studies have successfully identified valuable compounds from Polygonum roots that possessed medicinal properties. For example, researchers have found phytoestrogens from P. cuspidatum and P. hydropiper roots (Matsuda et al 2001), phytohormones, and anthraquinones from P. multiflorum roots (Yu et al 2006) and indigo from P. tinctorium roots (Chae et al 2000). We decided to target roots as the organ for elicitation process because of their ability to import and export molecules between root cells and the rhizosphere (Gleba et al 1999).…”