Phytoestrogens for menopausal vasomotor symptoms

Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study

“…The placebo effect of 58% noted in the current study is in agreement with that observed in the literature, and when a menopause-specific QoL questionnaire was used in a demographically similar population (28). The placebo effect in menopause studies may range from 1 to 59% with phytoestrogens (29), which is similar to the placebo effect noted with HRT for vasomotor symptoms (30) and a clinically significant 33% placebo effect has been observed with pharmaceutical products (31). To mitigate the placebo effect on menopausal symptoms especially on hot flush a sub-group analysis based on hot flush severity (at screening) was done.…”

Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study

“…The placebo effect of 58% noted in the current study is in agreement with that observed in the literature, and when a menopause-specific QoL questionnaire was used in a demographically similar population (28). The placebo effect in menopause studies may range from 1 to 59% with phytoestrogens (29), which is similar to the placebo effect noted with HRT for vasomotor symptoms (30) and a clinically significant 33% placebo effect has been observed with pharmaceutical products (31). To mitigate the placebo effect on menopausal symptoms especially on hot flush a sub-group analysis based on hot flush severity (at screening) was done.…”

Combination of Soy Isoflavones, 8-Prenylnaringenin and Melatonin Improves Hot Flashes and Health-Related Quality of Life Outcomes in Postmenopausal Women: Flavie Study

“…In this regard, some studies found a benefit compared with placebo [ 11 12 13 14 16 42 43 44 45 46 ], and others did not [ 47 48 49 ].The wide range in the amount of total isoflavones and the other active compounds, dose-schedule, time of follow-up and the severity of symptoms in these studies may explain these differences. Notably, in our study the reduction observed in overall and moderate-to-severe HFs seemed to surpass the estimated placebo effect described in other studies [ 38 ], similar to what has been described in the study of Nahas et al [ 13 ]. In this study, Nahas et al [ 13 ] found that isoflavones were significantly superior to placebo in reducing the frequency and severity of HFs ( P < 0.001) in postmenopausal women with a symptom profile similar to that reported in our study and a 10-month follow-up period.…”

Frequency of Phytoestrogen Consumption and Symptoms at Midlife among Bangladeshis in Bangladesh and London

“…In contrast, we found that the frequency of lignan intake was significantly associated with increased odds of hot flashes and decreased odds of vaginal dryness. The lack of a relationship between symptoms and the coumestrol consumption range is consistent with the lack of findings in supplementation studies [32]. In the meta-analysis of clinical trials mentioned above, the use of phytoestrogens was not associated with a change in the number of night sweats [36].…”

Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study

“…The placebo effect of 58% noted in the current study is in agreement with that observed in the literature, and when a menopause-specific QoL questionnaire was used in a demographically similar population (28). The placebo effect in menopause studies may range from 1 to 59% with phytoestrogens (29), which is similar to the placebo effect noted with HRT for vasomotor symptoms (30) and a clinically significant 33% placebo effect has been observed with pharmaceutical products (31). To mitigate the placebo effect on menopausal symptoms especially on hot flush a sub-group analysis based on hot flush severity (at screening) was done.…”

Combination of Soy Isoflavones, 8-Prenylnaringenin and Melatonin Improves Hot Flashes and Health-Related Quality of Life Outcomes in Postmenopausal Women: Flavie Study

“…In this regard, some studies found a benefit compared with placebo [ 11 12 13 14 16 42 43 44 45 46 ], and others did not [ 47 48 49 ].The wide range in the amount of total isoflavones and the other active compounds, dose-schedule, time of follow-up and the severity of symptoms in these studies may explain these differences. Notably, in our study the reduction observed in overall and moderate-to-severe HFs seemed to surpass the estimated placebo effect described in other studies [ 38 ], similar to what has been described in the study of Nahas et al [ 13 ]. In this study, Nahas et al [ 13 ] found that isoflavones were significantly superior to placebo in reducing the frequency and severity of HFs ( P < 0.001) in postmenopausal women with a symptom profile similar to that reported in our study and a 10-month follow-up period.…”

Frequency of Phytoestrogen Consumption and Symptoms at Midlife among Bangladeshis in Bangladesh and London

“…In contrast, we found that the frequency of lignan intake was significantly associated with increased odds of hot flashes and decreased odds of vaginal dryness. The lack of a relationship between symptoms and the coumestrol consumption range is consistent with the lack of findings in supplementation studies [32]. In the meta-analysis of clinical trials mentioned above, the use of phytoestrogens was not associated with a change in the number of night sweats [36].…”

Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study

“…The placebo effect of 58% noted in the current study is in agreement with that observed in the literature, and when a menopause-specific QoL questionnaire was used in a demographically similar population (28). The placebo effect in menopause studies may range from 1 to 59% with phytoestrogens (29), which is similar to the placebo effect noted with HRT for vasomotor symptoms (30) and a clinically significant 33% placebo effect has been observed with pharmaceutical products (31). To mitigate the placebo effect on menopausal symptoms especially on hot flush a sub-group analysis based on hot flush severity (at screening) was done.…”

Combination of Soy Isoflavones, 8-Prenylnaringenin and Melatonin Improves Hot Flashes and Health-Related Quality of Life Outcomes in Postmenopausal Women: Flavie Study

“…In this regard, some studies found a benefit compared with placebo [ 11 12 13 14 16 42 43 44 45 46 ], and others did not [ 47 48 49 ].The wide range in the amount of total isoflavones and the other active compounds, dose-schedule, time of follow-up and the severity of symptoms in these studies may explain these differences. Notably, in our study the reduction observed in overall and moderate-to-severe HFs seemed to surpass the estimated placebo effect described in other studies [ 38 ], similar to what has been described in the study of Nahas et al [ 13 ]. In this study, Nahas et al [ 13 ] found that isoflavones were significantly superior to placebo in reducing the frequency and severity of HFs ( P < 0.001) in postmenopausal women with a symptom profile similar to that reported in our study and a 10-month follow-up period.…”

Frequency of Phytoestrogen Consumption and Symptoms at Midlife among Bangladeshis in Bangladesh and London

“…In contrast, we found that the frequency of lignan intake was significantly associated with increased odds of hot flashes and decreased odds of vaginal dryness. The lack of a relationship between symptoms and the coumestrol consumption range is consistent with the lack of findings in supplementation studies [32]. In the meta-analysis of clinical trials mentioned above, the use of phytoestrogens was not associated with a change in the number of night sweats [36].…”