Phytoestrogen Supplements for the Treatment of Hot Flashes: The Isoflavone Clover Extract (ICE) Study

Comparison of the Effects of Licorice and Aerobic Exercise on the Quality of Life of Postmenopausal Women

“…Similar findings have also been reported by other studies [24,25]. Jeffrey et al [33] reported positive effects of licorice on the QoL, including the QoL in the sexual domain, of postmenopausal women. By contrast, the findings of the present study showed that the mean score of the QoL in the sexual domain increased after consuming licorice, indicating a decrease in the QoL in this domain.…”

Impact of dose, frequency of administration, and equol production on efficacy of isoflavones for menopausal hot flashes

“…This frequency/severity criterion was consistent with other studies, 26,41-43 and balanced considerations of participant representativeness 44 with the ability to detect a treatment effect, 18 e.g., avoiding a floor effect due to low baseline frequency. Additional criteria included willingness to record intensity and time of each hot flash in daily diaries, and to maintain current exercise and dietary patterns during the study.…”

Does scientific evidence support the use of non‐prescription supplements for treatment of acute menopausal symptoms such as hot flushes?

“…Notably, both studies showed a similar reduction in the frequency of symptoms, by 41% 53 or 44% 52 compared with baseline. However, a major difference was the magnitude of the placebo response compared with baseline, with a 36% decrease in the Tice study 53 compared with a 0% decrease in the van de Weijer and Barentsen study, 52 which allowed a significant treatment effect to emerge in the latter but not the former study. In a power‐based estimate of the sample size, Tice et al .…”