Phytoconstituent plumbagin: Chemical, biotechnological and pharmaceutical aspects

Badwaik, Hemant; Kumari, Leena; Nakhate, Kartik T.; Verma, Vinay Sagar; Sakure, Kalyani

doi:10.1016/b978-0-12-817901-7.00013-7

Cited by 29 publications

(12 citation statements)

References 207 publications

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“…The most prominent advantages of polymeric NPs include 1) efficient protection of therapeutics (especially labile molecules such as proteins) under physiological conditions, 2) controlled release of the cargo, 3) stealth behavior due to easy [122] functionalization and camouflaging, 4) superb biodistribution, 5) biocompatibility and biodegradability, and 6) no cytotoxicity against normal cells and tissues. [126][127][128] However, these NPs suffer from disadvantages such as 1) difficulty in scaling up, 2) good efficiency only for lipophilic drugs (and not for hydrophobic drugs), 3) low drug-encapsulating capacity, and 4) high fabrication costs. [129] Polymeric NPs can be assembled from amphiphilic block copolymers (ABCs) encompassing both hydrophilic and hydrophobic fragments within their covalently bound architecture.…”

Section: Polymeric Npsmentioning

confidence: 99%

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Beygi,

Oroojalian,

Azizi‐Arani

et al. 2024

Adv Funct Materials

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The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent junctions that regulates the transport of various materials and substances between the blood vasculature and the central nervous system (CNS). However, in cases of brain diseases, BBB's protective and regulatory effects hamper therapeutics from reaching affected sites in sufficient quantities. This has so far been a leading challenge in treating CNS diseases and disorders. For this problem to be overcome, recent research has sought to develop novel modalities to achieve efficient therapy and alleviate associated symptoms. Therefore, numerous strategies have operated in recent years to address the limitations of traditional and invasive methods, including poor brain penetration and serious side effects. As a desperately in‐demand technology, nanotheranostics has particularly shown promising results. Herein, this review reports recent advancements in CNS nanotheranostics and novel techniques and nanotechnology‐based strategies developed for treating neurodegenerative disorders. The study provides comprehensive data on the subject to be used for future studies for the therapy and management of CNS disorders and diseases.

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Section: Polymeric Npsmentioning

confidence: 99%

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Beygi,

Oroojalian,

Azizi‐Arani

et al. 2024

Adv Funct Materials

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“…The advantages of polymeric nanoparticles lie in their tunability and high encapsulation capability. On one hand, the morphological structures of the polymeric nanoparticles can be tuned by combining different monomer ratios 72 , 73 . On the other, if positively charged, polymers can bind with mRNAs through electrostatic interactions.…”

Section: Nanoparticle-mediated Mrna Delivery For Cancer Treatmentsmentioning

confidence: 99%

mRNA delivery in cancer immunotherapy

Zhong

Dong

2023

Acta Pharmaceutica Sinica B

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“…Throughout the past decade, significant progress has been made in the screeni naphthoquinones in Droseraceae [14][15][16][17][18][19][20][21][22], and although several papers aimed to ad these specific metabolites at various degrees of accuracy [1,[23][24][25], none of the r reviews represented their meanwhile known isomer distribution satisfactorily. It aim of the present account to fill this gap, so that chemotaxonomic considerations c based on adequate data.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility

Schlauer,

Fleischmann,

Hartmeyer

et al. 2024

Biology

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Chemotaxonomy is the link between the state of the art in analytical chemistry and the systematic classification and phylogenetic analysis of biota. Although the characteristic secondary metabolites from diverse biotic sources have been used in pharmacology and biological systematics since the dawn of mankind, only comparatively recently established reproducible methods have allowed the precise identification and distinction of structurally similar compounds. Reliable, rapid screening methods like TLC (Thin Layer Chromatography) can be used to investigate sufficiently large numbers of samples for chemotaxonomic purposes. Using distribution patterns of mutually exclusive naphthoquinones, it is demonstrated in this review how a simple set of chemical data from a representative sample of closely related species in the sundew family (Droseraceae, Nepenthales) provides taxonomically and phylogenetically informative signal within the investigated group and beyond.

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Phytoconstituent plumbagin: Chemical, biotechnological and pharmaceutical aspects

Cited by 29 publications

References 207 publications

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

mRNA delivery in cancer immunotherapy

Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility

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