Phytochemistry and Pharmacology ofCarthamus tinctoriusL.

Abstract

Carthamus tinctorius L. is a multifunctional cash crop. Its flowers and seeds are extensively used in traditional herbal medicine in China, Korea, Japan, and other Asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. More than 100 compounds have been isolated and identified from C. tinctorius. Flavonoids and alkaloids, especially the quinochalcone c-glycoside hydroxysafflor yellow A, N-(p-Coumaroyl)serotonin, and N-feruloylserotonin, are responsible for most of the pharmacological activities of C. tinctorius. In this paper, comprehensive and up-to-date information on the phytochemistry and pharmacology of C. tinctorius is presented. This information will be helpful for further explorations of the therapeutic potential of C. tinctorius and may provide future research opportunities.

Carthamus tinctorius L. extract activates insulin‐like growth factor‐I receptor signaling to inhibit FAS‐death receptor pathway and suppress lipopolysaccharides‐induced H9c2 cardiomyoblast cell apoptosis

“…Carthamus tinctorius L. has multifunctional uses and is being used as a traditional herbal medicine in China, Korea, and Japan for decades. It is used in treatments of various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis . Our previous studies have shown that C. tinctorius L. prevents LPS‐induced TNF‐α signaling activation and cell apoptosis by inhibiting JNK1/2‐NF‐kB pathway in H9c2 cardiomyoblast cells .…”

“…It is used in treatments of various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. 9,10 Our previous studies have shown that C. tinctorius L. prevents LPS-induced TNF-α signaling activation and cell apoptosis by inhibiting JNK1/2-NF-kB pathway in H9c2 cardiomyoblast cells. 11 In this study, we investigated the effect of CTF extract on LPS-induced FAS receptor and IGF-I signaling pathway in H9c2 cardiomyoblast cells.…”

The experimental evaluation of the protective effect of the extract of the cyclodextrin-containing phytotherapeutic composition on the development of osteoporosis

“…В связи с лекарственными ятрогениями стал возрождаться интерес к фитотерапии, которая признается одним из самых безопасных методов лечения острых и хронических заболеваний при условии, что этим занимается дипломированный врач, а не сам пациент. Однако данные по научному обоснованию и практике применения фитотерапии при ОП пока в основном представлены в зарубежной литературе [9][10][11][12][13][14][15][16][17][18][19]. В целом данные всех источников свидетельствуют о целесообразности использования тех или иных формул фитопрепаратов для профилактики и лечения ОП.…”

Hydroxysafflor Yellow A Suppresses MRC-5 Cell Activation Induced by TGF-β1 by Blocking TGF-β1 Binding to TβRII

“…Carthamus tinctorius L. has been used extensively as a traditional herbal medicine in China to treat various conditions, including gynecological, cardiovascular, and cerebrovascular diseases, as well as blood stasis and osteoporosis (Li et al, 2009; Han et al, 2016; Wang et al, 2016; Zhang et al, 2016). Over 100 compounds have been isolated from C. tinctorius L. and identified (Zhang et al, 2016), including hydroxysafflor yellow A (HSYA) as one of main active constituents.…”

“…Over 100 compounds have been isolated from C. tinctorius L. and identified (Zhang et al, 2016), including hydroxysafflor yellow A (HSYA) as one of main active constituents. Injection of safflor yellow (the main active ingredient of which is HSYA) achieved remarkable clinical effects in patients with cardiovascular and cerebrovascular diseases in China (Zhang et al, 2005; Yang et al, 2009; Li et al, 2015).…”