Phytochemicals isolated from the root bark of Sarcocephalus latifolius (Sm.) E.A.Bruce

Ajiboye, Abdulfatai Temitope; Asekun, Olayinka Taiwo; Familoni, Oluwole B.; Ali, Zulfiqar; Wang, Yanhong; Ghanadian, Mustafa; Zulfiqar, Fazila; Larbie, Christopher; Samuel, Odewo A.; Khan, Ikhlas A.

doi:10.1016/j.bse.2019.05.017

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…The phytochemical analysis of the crude extracts and the various fractions revealed the presence of saponins, tannins, glycosides, alkaloids, flavonoids, and oils in varying proportions. Ajiboye et al, 28 and Ene et al, 29 had also reported the presence of these phytochemicals in the root of this plant, consistent with the present study findings. Furthermore, Ajiboye et al, were able to further elucidate the structure of some of these phytochemicals, which will undoubtedly aid in developing therapeutic drugs from the plant.…”

Section: Resultssupporting

confidence: 92%

Antimicrobial Activity, Phytochemistry and Acute Toxicity Profile of Sarcocephalius latifolius Root Bark

2021

TJNPR

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Medicinal plants have been a source of medicinal agents for many years, and many chemotherapeutic drugs have their origin from plants. 1 The world health Organization (WHO) stated that medicinal plants are the best precursors for synthesizing new drugs. 2 In recent times, there is an increase in plant-based therapeutic products in both developed and developing countries because they are mostly nontoxic, have fewer side effects, and are available at affordable prices. 3 Medicinal plants are used widely in many parts of the world, especially in rural areas with limited access to modern medical and health facilities. 4 Even though orthodox medicines are now available for many debilitating ailments and disease conditions, there is a need to develop new therapeutic antimicrobial agents from medicinal plants due to the increasing toxicity and failure of many chemotherapeutics and antibiotics resistance exhibited by pathogenic microorganisms. [5][6][7] Medicinal plants have also been reported to have minimal or no side effects and have been found useful for practically almost every known ailment. Sarcocephalus latifolius (Smith), also called African peach, is a member of the plant family Rubiaceae. The plant is a small multistemmed tree with rounded-ovate leaves and bears red ball-like fruits. 8 The plant is widely distributed in several African countries, including, but not limited to,

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Section: Resultssupporting

confidence: 92%

Antimicrobial Activity, Phytochemistry and Acute Toxicity Profile of Sarcocephalius latifolius Root Bark

2021

TJNPR

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“…In total, 39 indole alkaloids were tentatively identified corresponding to peaks 1 , 2 , and 5 – 41 . Ajiboye et al reported strictosamide as the major compound that belongs to the monoterpene indole alkaloid class 29 . These indole alkaloid derivatives are the major compounds distributed among the bark and roots of S. latifolius based on their methanolic extracts.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of various phytochemicals in this plant, such as alkaloids, saponins, terpenoids, anthraquinone, sterols, flavonoids, and tannins, has been reported 20,27–35 . Alkaloids, such as strictosamide, naucleamides (A–E), 27 latifoliamides (1–5), 28 and 19‐ O ‐ethylangustoline, 20 have been reported to be present in the stem bark of this plant.…”

Section: Introductionmentioning

confidence: 84%

“…20,[27][28][29][30][31][32][33][34][35] Alkaloids, such as strictosamide, naucleamides (A-E), 27 latifoliamides (1-5), 28 and 19-Oethylangustoline, 20 have been reported to be present in the stem bark of this plant. Two indole alkaloids ( extract of S. latifolius 29 and polyphenolic content from the leaves and fruits using Folin-Ciocalteu reagent. 36 One paper reported a validated method for the quantification of strictosamide in the extract of the Nauclea pobeguinii stem bark.…”

Section: Introductionmentioning

confidence: 99%

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Strategy for the quality control of herbal preparations made of Sarcocephalus latifolius: Development and validation of a UHPLC‐PDA method for quantification of angustoline and strictosamide and chemical profiling using LC‐QToF

Tittikpina

Katragunta

Avula

et al. 2022

Phytochemical Analysis

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Introduction: Sarcocephalus latifolius is one of the most used plants in West African traditional medicine to treat malaria.Objective: The aim is to establish a strategy to control the quality of herbal preparations made from S. latifolius.Method: A UHPLC-PDA method was developed for the determination and quantification of the two main bioactive compounds (angustoline and strictosamide) in various parts of the plant. Additionally, an LC-QToF with electrospray ionization method is described for the identification and confirmation of compounds in samples of different parts of the plant.Results: With the UHPLC-PDA method, separation was achieved within 5 min using a C18 column stationary phase at a temperature of 45 C and a gradient system with a mobile phase of water and acetonitrile, both containing 0.1% formic acid. The method was validated for linearity, accuracy, precision (repeatability and intermediate precision), limit of detection (LOD), and limit of quantification (LOQ). The LOD and LOQ of angustoline were found to be 0.3 and 0.8 μg/ml, respectively, and those of strictosamide were found to be 0.1 and 0.3 μg/ml, respectively. Using the LC-QToF method, 90 secondary metabolites, including four isolated compounds from the plant's roots, were identified from leaf, bark, and root samples of S. latifolius. Conclusion:This work is the first to propose a strategy to control the quality of herbal preparations made from S. latifolius. The developed method allows the quantification of the main bioactive compounds and the established chemical profile allows to distinguish the plant from any other species.

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“…Two new indole alkaloids; 21-O-ethylstrictosamide aglycone and 21-O-methylstrictosamide aglycone, are present in the root of S. latifolius [10] . Recently, two bisdemosides tripeterpenoid glycosides (quinovic acid 3-O-α-Lrhamnopyranosyl 28;-β-D-glucopyranosyl ester and quinovic acid3-O-β-D-fucopyranosyl-28-β-D-glucopyranosyl ester) and a monodesmoside triterpenoid glycoside (quinovic acid3-O-β-Dglucopyranoside) were isolated for the first time from the ethanol root extract of S. latifolius [11] .…”

Section: Introductionmentioning

confidence: 99%

HPLC Profile of Phenolic Contents, Antioxidant and Antidiabetic Activities of Methanolic Extract of the Leaves of Sarcocephalus latifolius(Bruce, Smith) Grown in North Central Geopolitical Zone, Nigeria

2020

JJC

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Preliminary phytochemical screening of the n-butanol fraction of the methanol leaf extract of Sarcocephalus latifoliuswas carried out;its phenolic contents were quantified by HPLC. The in vitroantihyperglycemic and antioxidant activities of the fraction were evaluated.The results of the present study indicated that the leaves’extract contained phytochemicals,like phenols, flavonoids, alkaloids and glycosides.Phenolic compounds,such as garlic acid, catechin, ferrulic acid, p-coumaric acid, apigen-7-glucose, kaemferol, quercetin and amentoflavone,were quantified by HPLC. Moreover, the fraction of leaves’extract of S.latifoliusdemonstrated significant antioxidant and antihyperglyce-mic activities.The presence of these phytochemicals,especially phenols and flavonoids,in the leavesof S.latifoliustherefore justifiesitsmedicinal usefulness,as this plant has the potential to protect oxidative stress-induced ailments

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Phytochemicals isolated from the root bark of Sarcocephalus latifolius (Sm.) E.A.Bruce

Cited by 5 publications

References 23 publications

Antimicrobial Activity, Phytochemistry and Acute Toxicity Profile of Sarcocephalius latifolius Root Bark

Antimicrobial Activity, Phytochemistry and Acute Toxicity Profile of Sarcocephalius latifolius Root Bark

Strategy for the quality control of herbal preparations made of Sarcocephalus latifolius: Development and validation of a UHPLC‐PDA method for quantification of angustoline and strictosamide and chemical profiling using LC‐QToF

HPLC Profile of Phenolic Contents, Antioxidant and Antidiabetic Activities of Methanolic Extract of the Leaves of Sarcocephalus latifolius(Bruce, Smith) Grown in North Central Geopolitical Zone, Nigeria

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