Phytochemical Screenings, Thrombolytic Activity, Membrane Stabilizing Activity and Cytotoxic Properties of Polygonum hydropiper

Sharif, Shahjabeen; Ahmed, T; Haque, Md. Aminul; Bhuiyan, Mohiuddin Ahmed; Shahriar, Mohammad

doi:10.3923/rjmp.2014.92.98

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…The erythrocyte membrane resembles to lysosomal membrane and as such, the effect of drugs on the stabilization of erythrocyte could be extrapolated to the stabilization of lysosomal membrane 12 . The membrane stabilizing activity of the extractives was assessed by using hypotonic solution and heat induced methods 13 .…”

Section: Membrane Stabilizing Activitymentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:In the present study, the phytochemical screening, in vitro antioxidant activity, thrombolytic activity, membrane stabilizing activity, acute toxicity and antidepressant activity were evaluated using Forced Swimming Test (FST) of the root extract of Typhonium trilobatum. Phytochemical evaluation was done by performing different chemical tests and the presence of flavonoid, carbohydrate and phenol were detected in the root parts of the plant. Methanol, chloroform and ethanol were used as solvent in extraction process. Each extraction yield was analyzed using High Performance Liquid Chromatography (HPLC) to identify and measure the quantity of ascorbic acid. Total flavonoid content and total phenol content was also determined by UV-VIS Spectrophotometer. Ascorbic acid, flavonoid, phenol was found to be of higher concentration in ethanol extract compared with methanol and chloroform extract. Ethanol was suitable solvent in extraction process of Typhonium trilobatum. In vitro antioxidant activity of the root extracts was performed by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, cupric reducing anti-oxidant activity, scavenging of hydrogen peroxide and nitric oxide radical scavenging assay. These four methods were used to evaluate antioxidant activity and the root extract showed good potential. The root extract showed lower thrombolytic activity. Anti-depressant test was done by using forced swim test showed low dose anti-depressant activity. Our investigation suggests that Typhonium trilobatum roots contain high amount of ascorbic acid, phenolic and flavonoid compound which may be responsible for its biological activities in folkloric medicine.

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Section: Membrane Stabilizing Activitymentioning

confidence: 99%

“…The thrombolytic activity of all extracts of the plants was evaluated by using streptokinase (SK) as the standard 12 .…”

Section: Thrombolytic Activitymentioning

confidence: 99%

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2016

IJPSR

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“…Due to the low requirements for growth conditions, it has abundant wild plant resources what is more, it is widely distributed in China in Sichuan, Guangdong, Guangxi, and other places (Hong and Hanshen, 2013). Many studies have shown that P. hydropiper is rich in various chemical components, including flavonoids, terpenes, and organic acids, with antimicrobial, antioxidant, antiviral, insecticidal, and other biological activities (Rahman et al, 2002;Ayaz et al, 2014;Sharif et al, 2014;Shahed-Al-Mahmud and Lina, 2017). Due to different local standards, the large-scale commercial cultivation of P. hydropiper has not yet been achieved.…”

Section: Introductionmentioning

confidence: 99%

Interactive Effects of Plant Growth-Promoting Microbes and Nanoparticles on the Physiology, Growth, and Yield of Crops

Akram,

Ahmad,

Ahmad Yasin

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Due to the low requirements for growth conditions, it has abundant wild plant resources what is more, it is widely distributed in China in Sichuan, Guangdong, Guangxi, and other places (Hong and Hanshen, 2013 ). Many studies have shown that P. hydropiper is rich in various chemical components, including flavonoids, terpenes, and organic acids, with antimicrobial, antioxidant, antiviral, insecticidal, and other biological activities (Rahman et al, 2002 ; Ayaz et al, 2014 ; Sharif et al, 2014 ; Shahed-Al-Mahmud and Lina, 2017 ). Due to different local standards, the large-scale commercial cultivation of P. hydropiper has not yet been achieved.…”

Section: Introductionmentioning

confidence: 99%

Colonization characteristics of fungi in Polygonum hydropipe L. and Polygonum lapathifolium L. and its effect on the content of active ingredients

Zhang

Lv²,

Tian³

et al. 2022

Front. Plant Sci.

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Polygonum hydropiper, is a plant of the Persicaria genus, which is commonly used to treat various diseases, including gastrointestinal disorders, neurological disorders, inflammation, and diarrhea. However, because of different local standards of P. hydropiper, people often confuse it with Polygonum lapathifolium L. and other closely related plants. This poses a serious threat to the safety and efficacy of the clinical use of P. hydropiper. This study aims to determine the six active ingredients of P. hydropiper and P. lapathifolium. Then the endophytic fungi and rhizosphere soil of the two species were sequenced by Illumina Miseq PE300. The results show significant differences between the community composition of the leaves, stems, and roots of the P. hydropiper and the P. lapathifolium in the same soil environment. Of the six secondary metabolites detected, five had significant differences between P. hydropiper and P. lapathifolium. Then, we evaluated the composition of the significantly different communities between P. hydropiper and P. lapathifolium. In the P. hydropiper, the relative abundance of differential communities in the leaves was highest, of which Cercospora dominated the differential communities in the leaves and stem; in the P. lapathifolium, the relative abundance of differential community in the stem was highest, and Cladosporium dominated the differential communities in the three compartments. By constructing the interaction network of P. hydropiper and P. lapathifolium and analyzing the network nodes, we found that the core community in P. hydropiper accounted for 87.59% of the total community, dominated by Cercospora; the core community of P. lapathifolium accounted for 19.81% of the total community, dominated by Sarocladium. Of these core communities, 23 were significantly associated with active ingredient content. Therefore, we believe that the community from Cercospora significantly interferes with recruiting fungal communities in P. hydropiper and affects the accumulation of secondary metabolites in the host plant. These results provide an essential foundation for the large-scale production of P. hydropiper. They indicate that by colonizing specific fungal communities, secondary metabolic characteristics of host plants can be helped to be shaped, which is an essential means for developing new medicinal plants.

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Phytochemical Screenings, Thrombolytic Activity, Membrane Stabilizing Activity and Cytotoxic Properties of Polygonum hydropiper

Cited by 8 publications

References 13 publications

Untitled

Untitled

Interactive Effects of Plant Growth-Promoting Microbes and Nanoparticles on the Physiology, Growth, and Yield of Crops

Colonization characteristics of fungi in Polygonum hydropipe L. and Polygonum lapathifolium L. and its effect on the content of active ingredients

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