Phytochemical screening and in vitro pharmacological activities of methanolic leaves extract of Caryota mitis

Tona, Marzia Rahman; Tareq, Abu Montakim; Sayeed, M. S. R.; Mahmud, Md.; Jahan, Israt; Sakib, Shahenur Alam; Shima, Mutakabrun; Emran, Talha Bin

doi:10.5455/jabet.2020.d114

Cited by 7 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, alcoholic extracts of Areca catechu (Arecaceae) are anti-inflammatory and analgesic in carrageenaninduced inflammatory oedema in rats and in acetic acidinduced pain in mice (Lee et al, 2014;Barman et al, 2011). Similar results have been described with methanolic leaf extracts of Cocus nucifera, Hyophorbe verschaffeltii and Caryota mitis (Lima et al, 2015;Aly et al, 2016;Tona et al, 2020). Also, ethanolic leaves extract of Phoenix loureiroi Kunth (Arecaceae) possesses anti-inflammatory and analgesic effects in dose dependent manner in animal models (Mondal et al, 2021).…”

Section: Discussionsupporting

confidence: 69%

Anti-inflammatory and analgesic activities of methanolic extract of Elaeis guineensis Jacq. leaves (Arecaceae) and its fractions

Sene¹,

Firmin²,

Sarr³

et al. 2023

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Elaeis guineensis Jacq. is an arborescent monocotyledon of the Arecaceae family. It is a plant originated from tropical rainforest of West Africa. For centuries, it has been a source of food and a natural remedy against several pathologies. The aim of the present research was to evaluate antiinflammatory and analgesic activities of methanolic extract E. guineensis Jacq. (Arecaceae) leaves and phytochemical groups. Extraction with methanol and various liquid-liquid fractionations were carried out. These extract and fractions were administered orally at different doses. The experiments were performed on models of carrageenan-induced inflammatory edema in rat and acetic acid-induced pain in mouse. The extraction protocols gave a methanolic extract and different fractions, methanolic tannins free, alkaloid, terpenoid, and flavonoid. The methanolic extract administered at doses of 1, 3 and 10 mg/kg significantly prevents inflammatory edema. The percentages of increase in edema 5 h after induction are 38.31±3.55, 37.48±4.98, 40.82±4.14 versus 92.72±6.05 in the control group. The same profiles are observed with the methanolic fractions tannins free, flavonoid and terpene. However, the latter show dose-dependent activities between 1 and 3 mg/kg. The methanol fraction tannins free at 3 mg/kg is better in preventing inflammatory edema. Oral tannin-free methanolic fraction significantly prevents acetic acid-induced pain in mice. Elaeis guineensis leaves possess anti-inflammatory and analgesic properties on models of carrageenan-induced inflammatory edema in rat and acetic acidinduced pain in mouse. The anti-inflammatory and analgesic activities could be linked to the combined action of alkaloids, flavonoids and terpenes, on the different targets of the inflammatory reaction.

show abstract

Section: Discussionsupporting

confidence: 69%

Anti-inflammatory and analgesic activities of methanolic extract of Elaeis guineensis Jacq. leaves (Arecaceae) and its fractions

Sene¹,

Firmin²,

Sarr³

et al. 2023

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…In the present study, we exhibited that MECVL can play a crucial role in insomnia by reducing anxiety and depression through versatile mice models [34]. By using these animal models (open field and hole cross tests) we can determine how MECVL acts on rodents for sedative action [35]. The effect of sedation was mainly dose-dependent for MECVL.…”

Section: Discussionmentioning

confidence: 87%

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

et al. 2020

Self Cite

View full text Add to dashboard Cite

Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quantitative and qualitative phytochemical analysis, and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qualitative and quantitative studies were also performed through phytochemical screening and GC-MS analysis, and fifty-seven phytochemical compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the molecular docking analysis. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the respective receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

show abstract

“…The denaturation of several proteins can occur due to inflammatory activities, particularly in conditions such as arthritis. Protection against protein denaturation is a key mechanism associated with NSAID use, which also have a suppressive effect against cyclooxygenase, which is thought to play a large role in the arthritic inflammation process [13]. Indomethacin and phenylbutazone are examples of conventional NSAIDs, which not only block the enzymatic activities of COX but also prevent protein denaturation.…”

Section: Discussionmentioning

confidence: 99%

“…Anti-inflammatory MEMC activity was ascertained using a previously established albumin denaturation protocol, with slight modifications [13,14]. The preparation of the test solution (0.5 mL) included the test sample (0.05 mL) and 0.45 mL 5% (w/v) aqueous albumin solution prepared in distilled water (0.5 mL).…”

Section: In Vitro Anti-inflammatory Activitymentioning

confidence: 99%

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Shovo

Tona

Mouah

et al. 2021

CIMB

View full text Add to dashboard Cite

Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies.

show abstract

Phytochemical screening and in vitro pharmacological activities of methanolic leaves extract of Caryota mitis

Cited by 7 publications

References 0 publications

Anti-inflammatory and analgesic activities of methanolic extract of Elaeis guineensis Jacq. leaves (Arecaceae) and its fractions

Anti-inflammatory and analgesic activities of methanolic extract of Elaeis guineensis Jacq. leaves (Arecaceae) and its fractions

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Contact Info

Product

Resources

About