Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam

Anh, Hoang Le Tuan; Thảo, Đỗ Thị; Dung, Dương Thị; Kiệm, Phan Văn; Quang, Trần Hồng; Yến, Phạm Thị Hải; Tuan, Do Thanh; Cường, Phạm Việt; Cuong, Le Canh Viet; Hung, Tran Manh

doi:10.1016/j.phytol.2018.07.029

Cited by 18 publications

(18 citation statements)

References 12 publications

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“…71 Bioassaydirected isolation and purication of the crude extract of Withania coagulans led to the isolation of withacoagulins G (112), and its absolute stereochemistry was conrmed using the X-ray diffraction method. 73 (22R)-4a,17a,27-trihydroxy-1-oxowitha-2,5,24-trienolide (115), isolated from the leaves of Withania aristate, has an unusual 4a-hydroxy-2-en-1-one unit in ring A. 74 The orientations of the hydroxyl groups at C-14 and C-15 in exodeconolide F (116) have not been established because of the insufficient NOE correlations.…”

Section: The Classication Of Withanolidesmentioning

confidence: 99%

Natural withanolides, an update

et al. 2022

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Section: The Classication Of Withanolidesmentioning

confidence: 99%

Natural withanolides, an update

et al. 2022

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“…Cutleaf groundcherry had been reputed to be a weed and reduced crop production, but now many studies have begun to examine the benefits of cutleaf groundcherry. The cutleaf groundcherry contains phytochemical compounds that have the potential to be developed as anti-inflammatory (Bastos et al, 2008;Rivera et al, 2019), antibacterial (Yang et al, 2016;Erturk et al, 2017), anticancer (Fitria et al, 2011;Elkenawy et al, 2015;Tuan-Anh et al, 2018), antidiabetic (Zhang et al, 2018) and antitumour (Hseu et al, 2011) agents.…”

Section: Introductionmentioning

confidence: 99%

Effect of NPK Fertilizer on Nutrient Uptake, Growth, Yield and Beta-carotene of Cutleaf Groundcherry (Physalis angulata L.) of Genotypes

Yamika

Simbolon

Waluyo

et al. 2021

IJARe

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Background: Cutleaf groundcherry (Physalis angulata L.) has vitamins that are good for health. There were several genotypes of cutleaf groundcherry that have the potential to be widely cultivation, but information of doses of NPK fertilizer for those genotypes was still limited. The objective of this experiment was to determine the response of cutleaf groundcherry to different rates of NPK fertilizer. Methods: The experiment was conducted May - September 2019 in dry land field. The experiment used a factorial randomized block design with three replications. The first factor was genotypes cutleaf groundcherry (PA 01, PA 02 and PA 03) and the second factor was doses of NPK fertilizer (75, 150 and 225 kg ha-1 NPK). Conclusion: The increased in doses of NPK fertilizer to 225 kg ha-1 NPK increased nutrient uptake, plant growth and fresh fruit weight for each genotype of cutleaf groundcherry. Meanwhile ascorbic acid content increased with a dose of 150 kg ha-1 NPK, but decreased with increased NPK fertilizer rates. The beta-carotene content with 75 kg ha-1 NPK fertilizer was higher than with 150 and 225 kg ha-1 doses. The increase of NPK fertilizer doses otherwise decreases the beta-carotene content for each genotype. Shoot dry weight, fresh fruits weight and ascorbic acid in PA 03 genotype higher than PA 01 and PA 02 genotypes.

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“…Physagulins J ( 128 ) and M ( 152 ) were isolated from P. angulata . 128 showed significant cytotoxic activity against A549 cells with an IC 50 value of 8.27 μ m ; however, 152 exhibited potent inhibitory effect against PANC‐1 cells with an IC 50 value of 3.18 μ m . Physapubenolide ( 8 ) induced apoptosis and autophagosomes associated cell death through promoting ROS generation in MDA‐MB‐231 and MCF‐7 cells .…”

Section: Pharmacological Effectsmentioning

confidence: 99%

“…franchetii , known as ‘Jin‐Deng‐Long’ in China, was commonly adopted for the treatment of excessive phlegm, pharyngitis, cough, dysuria, pemphigus, etc; in South American traditional medicine, the fruits, calyxes and the leaves of P. philadelphica have diverse therapeutic effects against several human diseases: the fruits were used for the treatment of fever, cough and amygdalitis; the calyxes were used for treating diabetes; and the leaves could be adopted for the remedy of gastrointestinal disorders . Phytochemical and pharmacological investigations have indicated that withanolides are the predominant type of chemical constituents of the genus Physalis and are the main biological substances supporting the traditional uses of these plants . These data suggested that the genus Physalis was an important resource for discovering withanolide‐type molecules with potential therapeutic effect against human diseases.…”

Section: Introductionmentioning

confidence: 99%

Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects

Huang

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Withanolides are a group of modified C28 ergostane‐type steroids with a C‐22, C‐26 δ‐lactone side chain or a C‐23, C‐26 γ‐lactone side chain. They enjoy a limited distribution in the plant kingdom and predominantly occur in several genera of Solanaceae. Of which, the genus Physalis is an important resource for this type of natural molecules. The present review aims to comprehensively illustrate the structural characteristics and classification of withanolides, and particularly focus on the progression on phytochemical and pharmacological aspects of withanolides from Physalis ranging from January 2015 to June 2019. Key findings Approximately 351 natural withanolides with novel and unique structures have so far been identified from genus Physalis, mainly isolated from the species of P. angulata and P. peruviana. Withanolides demonstrated diverse biological activity, such as anticancer, anti‐inflammatory, antimicrobial, immunoregulatory, trypanocidal and leishmanicidal activity. Their observed pharmacological functions supported the uses of Physalis species in traditional or folk medicines. Summary Due to their unique structure skeleton and potent bioactivities, withanolides are regarded to be promising drug candidates, particularly for developing anticancer and anti‐inflammatory agents. Further investigations for discovering novel withanolides of genus Physalis, exploiting their pharmacological values and evaluating their potency as therapeutic agents are significant work.

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Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam

Cited by 18 publications

References 12 publications

Natural withanolides, an update

Natural withanolides, an update

Effect of NPK Fertilizer on Nutrient Uptake, Growth, Yield and Beta-carotene of Cutleaf Groundcherry (Physalis angulata L.) of Genotypes

Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects

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