Phytochemical analysis of a herbal tea from Artemisia annua L.

Carbonara, Teresa; Pascale, Rossana; Argentieri, Maria Pia; Papadia, Paride; Fanizzi, Francesco Paolo; Villanova, Luciano; Avato, Pinarosa

doi:10.1016/j.jpba.2012.01.015

Cited by 75 publications

(85 citation statements)

References 34 publications

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“…A. annua is rich in terpenoids, phenols, flavonoids, and other shikimate pathway metabolites (Brown, 2010;Carbonara et al, 2012). This plant is a major source of the sesquiterpene lactone artimisinin, which is one of the most efficient drugs used in the treatment of the infectious disease malaria (van der Kooy and Sullivan, 2013).…”

Section: Introductionmentioning

confidence: 99%

Germination and seedling growth of barley as affected by Artemisia annua water extract

Salman¹,

Salameh²,

Abu-Romman³

2017

Plant Omics

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Laboratory and greenhouse pot experiments were conducted to assess the allelopathic effects of Artemisia annua water extract on germination and growth of barley. Lower concentrations of A. annua water extract (0.5 and 1.0 %) did not affect the germination of barley seeds. However, higher concentrations (1.5-3.5 %) resulted in significant reductions in the germination percentage. Seedling growth of barley was also affected by A. annua water extract. Both shoot and root lengths were negatively affected by A. annua water extract and the degree of inhibition was concentration dependent. When barley seedlings were subjected to 0.5% extract concentration, shoot length was inhibited by 6% while root length showed 18.5% inhibition over control seedlings. The lowest shoot and root lengths were recorded at 3.0 and 3.5 % water extract. At 0.5 % extract concentration, shoot and root fresh and dry weights were significantly unaffected compared with the control. Shoot fresh weight was significantly unaltered when seedlings were treated with 1.0 % extract. However, at the same concentration root fresh weight, shoot dry weight, and root dry weight were inhibited by 44.7, 33.3, and 40 %, respectively. The present results confirmed that root growth (length and weight) was more sensitive to A. annua water extract than shoot growth. The present results also indicated the presence of water soluble allelochemicals in A. annua that are able to inhibit growth of barley.

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Section: Introductionmentioning

confidence: 99%

Germination and seedling growth of barley as affected by Artemisia annua water extract

Salman¹,

Salameh²,

Abu-Romman³

2017

Plant Omics

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“…They did conclude that the low extraction efficiency of these flavonoids in the tea infusion ruled out synergism, and suggested using capsules containing the leaf material over the tea infusion . Carbonara et al (2012) also noted that flavonoids were not very abundant in the tea infusion, and observed the infusions to be rich in caffeic acid derivatives. They identified 25 phenolic compounds within Artemisia annua tea infusions and 27 phenolics in Artemisia annua water extracts after 1, 24 and 48 h periods.…”

Section: Identification Of Other Compounds In the Artemisia Annua Formentioning

confidence: 98%

“…2) since antiquity (Carbonara et al, 2012). We assume that the tea infusion, which is currently being used, originated due to the preparation speed (minutes vs hours) even though this method was not originally described in the ancient texts.…”

Section: Chemistry Of Artemisia Annua Infusions and The Influence Of mentioning

confidence: 99%

“…Over the years, more than 600 secondary metabolites have been identified and reported for Artemisia annua (Brown, 2010) while only 37 compounds have been identified in tea infusions or cold water extracts, mainly consisting of caffeic acid derivatives, flavonoids, coumarins and artemisinin (Elford et al, 1987;Liu et al, 2006;D'angelo et al, 2009;De Oliveira et al, 2009;Weathers et al, 2011). The Artemisia genus as a whole has been reported to include a large variety of terpenes, phenols and acetylenes, along with coumarins and flavonoids (Carbonara et al, 2012). Liu et al (2010) conducted a metabolomic investigation on Artemisia afra in relation to Artemisia annua, identifying 26 compounds, of which 23 were common in both species.…”

Section: Identification Of Other Compounds In the Artemisia Annua Formentioning

confidence: 99%

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The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives

Kooy

Sullivan

2013

Journal of Ethnopharmacology

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“…Crude acetone, water and methanol can be used to determined phenolic compositions of A. annua by HPLC-DAD-ESI/MS n (IUPAC, 1976;Carbonara et al, 2012;.Gouveia & Castilho, 2013) but these compounds have not been fully studied so far. For this reason, it is necessary to develop a rapid and sensitive method to identify these components in A. annua.…”

Section: Introductionmentioning

confidence: 99%

Identification and purification of novel chlorogenic acids in Artemisia annua L.

Zhao¹,

Zhang²,

Chen³

et al. 2015

JEBAS

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Present work has been carried out to study the identification and purification of chlorogenic acids in Artemisia annua L. Thirty-six chlorogenic acids were identified from this plant. Among these fifteen viz. two monocaffeoylquinic acids (Mr354), five dicaffeoylquinic acids (Mr516), one feruloylquinic acid (Mr368), three caffeoylferuloylquinic acids (Mr530), two ferulylquinic acids (Mr544), one dimethoxy-cinnamoylquinic acid (Mr382) and one p-coumaroylquinic acid (Mr338) were reported first time in present study by LC/MS n . Cis-isomers of these chlorogenic acids were also identified.Furthermore, column chromatography was used for the separation and purification of these chlorogenic acid; by the use of petroleum ether and ethyl acetate decolorization methods as mentioned in the literature, thus separation and purification process carried out at the same time. Polyamide and dextran were also used to purify Dicaffeoylquinic acid and purity level reached 85.7% with a yield of 53.4% after the secondary purification by Sephadex LH-20. Result of study revealed that A. annua can not only used for the production of artemisinin, but also yielding different kinds of chlorogenic acids, thus making comprehensive utilization of this plant.

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Phytochemical analysis of a herbal tea from Artemisia annua L.

Cited by 75 publications

References 34 publications

Germination and seedling growth of barley as affected by Artemisia annua water extract

Germination and seedling growth of barley as affected by Artemisia annua water extract

The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives

Identification and purification of novel chlorogenic acids in Artemisia annua L.

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