Phytochemical analysis, characterization, and biosynthesis of gold nanoparticles, zinc oxide nanoparticles, and gold-zinc oxide nanocomposites from phoenix dactylifera L. seeds: Biological evaluation

Chamkouri, Narges; Koolivand, Zahra; Niazvand, Firooze; Mojaddami, Ayyub

doi:10.1016/j.inoche.2023.111146

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Gold and zinc oxide nanoparticles, along with nanocomposite of gold and zinc oxide, were synthesized by employing natural fibers extracted from Phoenix dactylifera L . seeds to act as both capping and stabilizing agents ( Chamkouri et al, 2023 ). Observations indicated that greater antibacterial efficacy against S. aureus and K. pneumoniae was achieved when the metals were applied as nanocomposites, surpassing their individual applications, while simultaneously exhibiting low toxicity to cells.…”

Section: Phytochemical Nanocompositementioning

confidence: 99%

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Saravanan,

Subramani,

Rajaramon

et al. 2023

Front. Pharmacol.

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Nanocomposites, formed by combining a matrix (commonly polymer or ceramic) with nanofillers (nano-sized inclusions like nanoparticles or nanofibers), possess distinct attributes attributed to their composition. Their unique physicochemical properties and interaction capabilities with microbial cells position them as a promising avenue for infectious disease treatment. The escalating prevalence of multi-drug resistant bacteria intensifies the need for alternative solutions. Traditional approaches involve antimicrobial agents like antibiotics, antivirals, and antifungals, targeting specific microbial aspects. This review presents a comprehensive overview of diverse nanocomposite types and highlights the potential of tailored matrix and antibacterial agent selection within nanocomposites to enhance treatment efficacy and decrease antibiotic resistance risks. Challenges such as toxicity, safety, and scalability in clinical applications are also acknowledged. Ultimately, the convergence of nanotechnology and infectious disease research offers the prospect of enhanced therapeutic strategies, envisioning a future wherein advanced materials revolutionize the landscape of medical treatment.

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Section: Phytochemical Nanocompositementioning

confidence: 99%

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Saravanan,

Subramani,

Rajaramon

et al. 2023

Front. Pharmacol.

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Investigating the Potential of Green-Fabricated Zinc Oxide Nanoparticles to Inhibit the Foodborne Pathogenic Bacteria Isolated from Spoiled Fruits

Fouda,

Abdel-Rahman,

Eid

et al. 2024

Catalysts

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In the current investigation, the antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) formed by an aqueous extract of Psidium guajava leaves against foodborne pathogenic bacterial strains was investigated. To achieve this goal, 33 bacterial isolates were obtained from spoiled fruits. Among these isolates, 79% showed cellulase activity, 82% showed amylase activity, 81% exhibited xylanase potential, and 65% exhibited lipase activity. Moreover, 12 isolates showed complete hemolysis (β-hemolysis). The identification of these isolates was done using sequencing and amplification of 16s rRNA as Staphylococcus aureus (two strains), Pseudomonas syringae (one strain), E. coli (two strains), Salmonella typhimurium (two strains), Listeria monocytogenes (one isolate), Bacillus cereus (two isolates), and Bacillus subtilis (two isolates). The formed ZnO-NPs by aqueous Psidium guajava leaf extract were characterized using UV, FT-IR, TEM, EDX, XRD, DLS, and Zeta potential. The data revealed the successful formation of a spherical shape, crystallographic structure, and well-arranged ZnO-NPs. FT-IR showed the effect of different functional groups in the plant extract in the formation of ZnO-NPs through reducing, capping, and stabilizing of end products. Moreover, EDX analysis showed that the Zn ion occupied the main component of the produced NPs. Interestingly, the obtained bacterial strains showed varied sensitivity toward green-synthesized ZnO-NPs. The growth inhibition of foodborne pathogenic strains by ZnO-NPs was concentration dependent, forming a zone of inhibition in the range of 20–23 mm at a concentration of 200 µg mL−1, which decreased to 15–18 mm at 100 µg mL−1. Moreover, the values of MIC were 25 and 50 µg mL−1 based on the bacterial strain. Overall, the green-synthesized ZnO-NPs can be a useful approach for inhibiting the growth of spoilage bacterial strains that destroy fruits and hence reduce the harmful effects of traditional treatment methods on the environment and human health.

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Impact of ZnO nanoparticles on MagA gene expression in Klebsiella pneumoniae isolated from diabetic foot ulcers

Jadooa,

Al-Mousawi,

Al-bderee

2024

APJMBB

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Diabetes mellitus (DM) is an accumulation of glucose in the blood. Diabetic mellitus is divided into gestational diabetes, type 1 and type 2. Complications of diabetes mellitus include diabetic foot ulcers. The most important complication of diabetic foot ulcers is bacterial infection, which leads to gangrene when various types of antibiotics fail to prevent bacterial infections. To explore the effect of synthetic zinc oxide nanoparticles (ZnONPs) on the expression of the MagA gene in Klebsiella pneumoniae isolated from diabetic foot ulcer cases. ZnONPs were biosynthesized by Aspergillus niger and characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD), and UV-visible spectroscopy. The inhibitory effect of ZnONPs on K. pneumoniae isolates was examined by determining the minimum inhibitory concentration (MIC) of the ZnONPs. Besides, the values of the MagA gene before and after exposure to ZnONPs would be examined by RT-qPCR, with 16SrRNA gene as the reference gene. According to SEM and XRD results, the ZnONPs are in the form of nanocrystals and have small spherical crystals with an average size of 13.5 nm. The highest optical density of the synthesized nanoparticles was obtained at 390 nm. The biosynthesized ZnONPs exhibit a strong inhibition zone against K. pneumoniae corresponding to 125 μg/mL. The fold of gene expression ranged from 0.042 to 0.118. The research reveals that ZnONPs exhibit strong antibacterial potential and affect gene expression in K. pneumoniae strains. The results of the present study indicate that ZnONPs can indeed be used in the treatment of infectious bacteria.

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Phytochemical analysis, characterization, and biosynthesis of gold nanoparticles, zinc oxide nanoparticles, and gold-zinc oxide nanocomposites from phoenix dactylifera L. seeds: Biological evaluation

Cited by 3 publications

References 31 publications

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Investigating the Potential of Green-Fabricated Zinc Oxide Nanoparticles to Inhibit the Foodborne Pathogenic Bacteria Isolated from Spoiled Fruits

Impact of ZnO nanoparticles on MagA gene expression in Klebsiella pneumoniae isolated from diabetic foot ulcers

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